Template:SUIT PGM low ADP: Difference between revisions

Revision as of 16:29, 20 December 2023

The addition of fuel substrates may trigger a transient peak increase in mitochondrial respiration due to the presence of low ADP concentrations, and reduction of the NAD pool. Once ADP is phosphorylated to ATP the respiration decreases and a further reduction of NAD can be observed.

In the presence of ATPases in the sample, ATP is recycled to ADP, making it not possible to measure LEAK state.

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	The addition of ~~PGM~~ may trigger a transient peak increase in mitochondrial respiration due to the presence of low ADP concentrations, and reduction of the NAD pool. Once ADP is phosphorylated to ATP the respiration decreases and a further reduction of NAD can be observed.		The addition of fuel substrates may trigger a transient peak increase in mitochondrial respiration due to the presence of low [[ADP]] concentrations, and reduction of the [[NAD]] pool. Once [[ADP]] is phosphorylated to [[ATP]] the respiration decreases and a further reduction of [[NAD]] can be observed.
	*In the presence of ATPases in the sample, ATP is recycled to ADP, making it not possible to measure LEAK state.		*In the presence of [[ATPases]] in the sample, [[ATP]] is recycled to [[ADP]], making it not possible to measure [[LEAK]] state.