Difference between revisions of "Etomoxir"
From Bioblast
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{{MitoPedia | {{MitoPedia | ||
|abbr=Eto | |abbr=Eto | ||
|description='''Etomoxir''' (Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. Eto inhibits the transport of the long-chain fatty acids from the cytosol into the mitochondrial matrix, thereby blocking the formation of acyl carnitines in the cytosol, leading finally to inhibition of the fatty acid oxidation. Of note, in contrast to long-chain fatty acids, the transport of short- and medium chain fatty acids is carnitine-independent. | |description='''Etomoxir''' (Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. Eto inhibits the transport of the long-chain fatty acids from the cytosol into the mitochondrial matrix, thereby blocking the formation of acyl carnitines in the cytosol, leading finally to inhibition of the fatty acid oxidation. Of note, in contrast to long-chain fatty acids, the transport of short- and medium chain fatty acids is carnitine-independent. The commercially available white compound is soluble in water. | ||
The commercially available white compound is soluble in water. | |||
|info= | |info= | ||
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|mitopedia topic=Inhibitor | |mitopedia topic=Inhibitor | ||
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ย | [[File:Etomoxir structure.png|right|300px|File:Etomoxir structure]] | ||
== Application in [[HRFR]] == | == Application in [[HRFR]] == | ||
::::*'''Eto (Etomoxir):''' ((+)-Etomoxir sodium salt hydrate); Sigma Aldrich; E-1905; storage: 2-8 ยฐC; FW= 338.76 ย | ::::*'''Eto (Etomoxir):''' ((+)-Etomoxir sodium salt hydrate); Sigma Aldrich; E-1905; storage: 2-8 ยฐC; FW= 338.76 ย | ||
::::*'''Caution:'''ย Store tightly sealed, protected from exposure to light. Acute toxicity (oral, dermal, inhalation.ย Dust mask or eyeshields, faceshields and gloves are recommended by the preparation. | ::::*'''Caution:'''ย Store tightly sealed, protected from exposure to light. Acute toxicity (oral, dermal, inhalation.ย Dust mask or eyeshields, faceshields and gloves are recommended by the preparation. |
Revision as of 21:29, 4 January 2018
Description
Etomoxir (Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. Eto inhibits the transport of the long-chain fatty acids from the cytosol into the mitochondrial matrix, thereby blocking the formation of acyl carnitines in the cytosol, leading finally to inhibition of the fatty acid oxidation. Of note, in contrast to long-chain fatty acids, the transport of short- and medium chain fatty acids is carnitine-independent. The commercially available white compound is soluble in water.
Abbreviation: Eto
MitoPedia topics:
Inhibitor
Application in HRFR
- Eto (Etomoxir): ((+)-Etomoxir sodium salt hydrate); Sigma Aldrich; E-1905; storage: 2-8 ยฐC; FW= 338.76
- Caution: Store tightly sealed, protected from exposure to light. Acute toxicity (oral, dermal, inhalation. Dust mask or eyeshields, faceshields and gloves are recommended by the preparation.