Difference between revisions of "O2k-Publications: Neuroblastoma"
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'''Neuroblastoma''' (NB) cell lines are transformed, neural crest derived cells, capable of unlimited proliferation ''in vitro''. These cell lines retain the ability of differentiation into neuronal cell types on treatment with various agents. This ability of NB cells to proliferate as well as to differentiate makes it an excellent ''in vitro'' system for [http://www.ncbi.nlm.nih.gov/pubmed/11328706 various studies]. | '''Neuroblastoma''' (NB) cell lines are transformed, neural crest derived cells, capable of unlimited proliferation ''in vitro''. These cell lines retain the ability of differentiation into neuronal cell types on treatment with various agents. This ability of NB cells to proliferate as well as to differentiate makes it an excellent ''in vitro'' system for [http://www.ncbi.nlm.nih.gov/pubmed/11328706 various studies]. | ||
'''SH-SY5Y''' cells are a human derived cell line. The original cell line, called SK-N-SH, from which it was subcloned, was isolated from a bone marrow biopsy taken from a four year-old female with neuroblastoma. | '''SH-SY5Y''' cells are a human derived cell line. The original cell line, called SK-N-SH, from which it was subcloned, was isolated from a bone marrow biopsy taken from a four year-old female with neuroblastoma. | ||
Other human neuroblastoma cell lines: LAN-1, IMR-32 (N-type) and SK-N-AS (S-type). | |||
Revision as of 17:51, 12 February 2013
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Neuroblastoma (NB) cell lines are transformed, neural crest derived cells, capable of unlimited proliferation in vitro. These cell lines retain the ability of differentiation into neuronal cell types on treatment with various agents. This ability of NB cells to proliferate as well as to differentiate makes it an excellent in vitro system for various studies.
SH-SY5Y cells are a human derived cell line. The original cell line, called SK-N-SH, from which it was subcloned, was isolated from a bone marrow biopsy taken from a four year-old female with neuroblastoma.
Other human neuroblastoma cell lines: LAN-1, IMR-32 (N-type) and SK-N-AS (S-type).
