Petit 2013 Abstract MiP2013

Petit PX (2013) The cardiolipin defect linked to a tafazzin mutation in Barth syndrome disturbs mitochondrial metabolism, alters apoptosis and autophagic fluxes but does not affect cell cycle progression. Mitochondr Physiol Network 18.08.

Link:

Petit PX (2013)

Event: MiP2013

Labels: MiParea: Respiration, mtDNA;mt-genetics, mt-Medicine, Patients  Pathology: Inherited 

Organism: Human  Tissue;cell: Blood cells  Preparation: Permeabilized cells, Homogenate  Enzyme: Complex I, Complex IV; Cytochrome c Oxidase"Complex IV; Cytochrome c Oxidase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property., Complex V; ATP Synthase"Complex V; ATP Synthase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property.  Regulation: mt-Membrane potential  Coupling state: LEAK, OXPHOS, ETS"ETS" is not in the list (LEAK, ROUTINE, OXPHOS, ET) of allowed values for the "Coupling states" property. 

HRR: Oxygraph-2k 

MiP2013 

Affiliations, acknowledgements and author contributions

Pharmacology, Experimental Toxicology and Cellular Signaling, CNRS / INSERM UMR S-747, Paris, France

Email: patrice.petit@inserm.fr

References

1. Gonzalvez F, D´Aurelio M, Boutant M, Moustapha A, Puech JP, Landes T, Arnauné-Pelloquin L, Vial G, Taleux N, Slomianny C, Wanders RJ, Houtkooper RH, Bellenguer P, Møller IM, Gottlieb E, Vaz FM, Manfredi G, Petit PX (2013) Barth syndrome: cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin (TAZ) gene mutation. Biochim Biophys Acta 1832: 1194-1206.

1. Gonzalvez F, Schug ZT, Houtkooper RH, Mackenzie ED, Brooks DG, Wanders RJ, Petit RJ, Vaz FM, Gottlieb E (2008) Cardiolipin provides an essential activating plateforme for caspase-8 on mitochondria. J Cell Biol 183: 681-696.