Rosenfeld 2003 Yeast: Difference between revisions
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|abstract=''Saccharomyces cerevisiae'' is a facultative anaerobe devoid of mitochondrial alternative oxidase. In this yeast, the structure and biogenesis of the respiratory chain, on the one hand, and the functional interactions of oxidative phosphorylation with the cellular energetic metabolism, on the other, are well documented. However, to our knowledge, the molecular aspects and the physiological roles of the non-respiratory pathways that utilize molecular oxygen have not yet been reviewed. In this paper, we review the various non-respiratory pathways in a global context of utilization of molecular oxygen in S. cerevisiae. The roles of these pathways are examined as a function of environmental conditions, using either physiological, biochemical or molecular data. Special attention is paid to the characterization of the so-called 'cyanide-resistant respiration' that is induced by respiratory deficiency, catabolic repression and oxygen limitation during growth. Finally, several aspects of oxygen sensing are discussed. | |abstract=''Saccharomyces cerevisiae'' is a facultative anaerobe devoid of mitochondrial alternative oxidase. In this yeast, the structure and biogenesis of the respiratory chain, on the one hand, and the functional interactions of oxidative phosphorylation with the cellular energetic metabolism, on the other, are well documented. However, to our knowledge, the molecular aspects and the physiological roles of the non-respiratory pathways that utilize molecular oxygen have not yet been reviewed. In this paper, we review the various non-respiratory pathways in a global context of utilization of molecular oxygen in S. cerevisiae. The roles of these pathways are examined as a function of environmental conditions, using either physiological, biochemical or molecular data. Special attention is paid to the characterization of the so-called 'cyanide-resistant respiration' that is induced by respiratory deficiency, catabolic repression and oxygen limitation during growth. Finally, several aspects of oxygen sensing are discussed. | ||
|keywords=Non-respiratory pathways, ROS, P450, Yeast; ''Saccharomyces cerevisiae''; Oxygen; Aerobiosis; Anaerobiosis;ย Cyanide-resistant respiration; Oxygen sensing | |keywords=Non-respiratory pathways, ROS, P450, Yeast; ''Saccharomyces cerevisiae''; Oxygen; Aerobiosis; Anaerobiosis;ย Cyanide-resistant respiration; Oxygen sensing | ||
|mipnetlab=FR La Rochelle Rosenfeld E, FR Pessac | |mipnetlab=FR La Rochelle Rosenfeld E, FR Pessac Diolez P | ||
|discipline=Mitochondrial Physiology, Environmental Physiology; Toxicology, Pharmacology; Biotechnology | |discipline=Mitochondrial Physiology, Environmental Physiology; Toxicology, Pharmacology; Biotechnology | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area=Respiration, mt-Biogenesis;mt-density | |area=Respiration, mt-Biogenesis;mt-density | ||
|organism=Saccharomyces cerevisiae | |diseases=Aging;senescence | ||
|injuries=Ischemia-reperfusion, Oxidative stress;RONS | |||
|organism=Saccharomyces cerevisiae, Fungi | |||
|preparations=Intact cells, Oxidase;biochemical oxidation | |preparations=Intact cells, Oxidase;biochemical oxidation | ||
|enzymes=Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase | |enzymes=Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase | ||
|topics=Aerobic glycolysis, Redox state, Substrate | |topics=Aerobic glycolysis, Redox state, Substrate | ||
| | |pathways=ROX | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=Spectrophotometry; Spectrofluorimetry | |additional=Spectrophotometry; Spectrofluorimetry | ||
|discipline=Mitochondrial Physiology, Environmental Physiology; Toxicology, Pharmacology; Biotechnology | |discipline=Mitochondrial Physiology, Environmental Physiology; Toxicology, Pharmacology; Biotechnology | ||
}} | }} |
Latest revision as of 12:44, 16 February 2018
Rosenfeld E, Beauvoit B (2003) Role of the non-respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae. Yeast 20:1115-44. |
Rosenfeld E, Beauvoit B (2003) Yeast
Abstract: Saccharomyces cerevisiae is a facultative anaerobe devoid of mitochondrial alternative oxidase. In this yeast, the structure and biogenesis of the respiratory chain, on the one hand, and the functional interactions of oxidative phosphorylation with the cellular energetic metabolism, on the other, are well documented. However, to our knowledge, the molecular aspects and the physiological roles of the non-respiratory pathways that utilize molecular oxygen have not yet been reviewed. In this paper, we review the various non-respiratory pathways in a global context of utilization of molecular oxygen in S. cerevisiae. The roles of these pathways are examined as a function of environmental conditions, using either physiological, biochemical or molecular data. Special attention is paid to the characterization of the so-called 'cyanide-resistant respiration' that is induced by respiratory deficiency, catabolic repression and oxygen limitation during growth. Finally, several aspects of oxygen sensing are discussed. โข Keywords: Non-respiratory pathways, ROS, P450, Yeast; Saccharomyces cerevisiae; Oxygen; Aerobiosis; Anaerobiosis; Cyanide-resistant respiration; Oxygen sensing
โข O2k-Network Lab: FR La Rochelle Rosenfeld E, FR Pessac Diolez P
Labels: MiParea: Respiration, mt-Biogenesis;mt-density
Pathology: Aging;senescence
Stress:Ischemia-reperfusion, Oxidative stress;RONS
Organism: Saccharomyces cerevisiae, Fungi
Preparation: Intact cells, Oxidase;biochemical oxidation Enzyme: Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase Regulation: Aerobic glycolysis, Redox state, Substrate
Pathway: ROX HRR: Oxygraph-2k
Spectrophotometry; Spectrofluorimetry