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Property "Has-20abstract" (as page type) with input value "The-20Himalayan-20Sherpas,-20a-20human-20population-20of-20Tibetan-20descent,-20are-20highly-20adapted-20to-20life-20in-20the-20hypobaric-20hypoxia-20of-20high-20altitude.-20Mechanisms-20involving-20enhanced-20tissue-20oxygen-20delivery-20in-20comparison-20to-20Lowlander-20populations-20have-20been-20postulated-20to-20play-20a-20role-20in-20such-20adaptation.-20Whether-20differences-20in-20tissue-20oxygen-20utilization-20(i.e.,-20metabolic-20adaptation)-20underpin-20this-20adaptation-20is-20not-20known,-20however.-20We-20sought-20to-20address-20this-20issue,-20applying-20parallel-20molecular,-20biochemical,-20physiological,-20and-20genetic-20approaches-20to-20the-20study-20of-20Sherpas-20and-20native-20Lowlanders,-20studied-20before-20and-20during-20exposure-20to-20hypobaric-20hypoxia-20on-20a-20gradual-20ascent-20to-20Mount-20Everest-20Base-20Camp-20(5,300-20m).-20Compared-20with-20Lowlanders,-20Sherpas-20demonstrated-20a-20lower-20capacity-20for-20fatty-20acid-20oxidation-20in-20skeletal-20muscle-20biopsies,-20along-20with-20enhanced-20efficiency-20of-20oxygen-20utilization,-20improved-20muscle-20energetics,-20and-20protection-20against-20oxidative-20stress.-20This-20adaptation-20appeared-20to-20be-20related,-20in-20part,-20to-20a-20putatively-20advantageous-20allele-20for-20the-20peroxisome-20proliferator-2Dactivated-20receptor-20A-20(PPARA)-20gene,-20which-20was-20enriched-20in-20the-20Sherpas-20compared-20with-20the-20Lowlanders.-20Our-20findings-20suggest-20that-20metabolic-20adaptations-20underpin-20human-20evolution-20to-20life-20at-20high-20altitude,-20and-20could-20have-20an-20impact-20upon-20our-20understanding-20of-20human-20diseases-20in-20which-20hypoxia-20is-20a-20feature." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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