- high-resolution terminology - matching measurements at high-resolution
Tetraphenylphosphonium
Description
Tetraphenylphosphonium (TPP+). A lipophilic molecular probe in conjunction with an ion selective electrode (ISE) for measuring the mitochondrial membrane potential.
See also: External unspecific binding of TPP+ and Internal unspecific binding of TPP+.
Abbreviation: TPP+
Reference: MiPNet14.05
- First TPP publication with HRR Brown 2011 Am J Physiol Regul Integr Comp Physiol
TPP+ inhibitory effect
MitoPedia O2k and high-resolution respirometry:
O2k-Open Support
- For measurement of mitochondrial membrane potential, the inhibitory concentration of the probe molecule should be evaluated on the activity of respiration MiPNet14.05. This side effect of TPP+ and TPMP+ (and various dyes) is frequently ignored.
