User talk:Beno Marija/MitO2 Kit Produktseite

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User talk:Beno Marija/MitO2 Kit Produktseite

O2k-Catalogue

Description Cell permeable compound - Mito-CII-Kit, 2 vials; 1 vial of NV118 (25 mg) + 1 vial of NV161 (10 mg)
Product ID 60200-01
Type O2k
Link
MitoPedia: Mito-CII
MitoPedia: Mito-CII
Image

Compounds

Cell permeable compounds NV118 and NV161 - Mito-CII-Kit

Preparation

  • The prodrug NV118 is dissolved in DMSO to 1M concentration and stored in aliquots at -20.
  • The prodrug NV161 is dissolved in DMSO to 1M concentration and stored in aliquots at -20.


Publications in the MiPMap
O2k-Protocols
Cell permeable compound - Mito-CII-Kit.

» Bioblast pdf » Versions

Oroboros (2019-03-01) Mitochondr Physiol Network

Abstract: Gnaiger E, Bastos A, Laner V, Passrugger M, NeuroVive Pharmaceutical AB (2019) cell permeable compound - Mito-CII-Kit. Mitochondr Physiol Network 24.03(01):1-2.

(##) The cell permeable compound Mito-CII-Kit is the first generation of NeuroVive Pharmaceutical AB's succinate/malonate prodrugs and was developed to stimulate and inhibit Complex II of the respiratory electron transfer system in intact cells, and will expand the toolbox for evaluating the role of mitochondria in disease.

» Product: Oroboros O2k, O2k-Catalogue

Keywords: Mito-CII-Kit

O2k-Network Lab: AT_Innsbruck_Oroboros, NeuroVive


Compounds of Mito-CII-Kit

The Mito-CII-Kit is composed of equal quantities of the following Compounds:
  • Cell permeable compound NV118
Description: Succinate prodrug: C10H14O8, Molecular weight 262,2g.mol-1
Aliquots per 25 mg


  • Cell permeable compound NV161
Description: Malonate prodrug: C9H12O8, Molecular weight 248,2g.mol-1
Aliquots per 10 mg


  • Reference:
Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency. Nat Commun 7:12317. »Bioblast link« - Original publication introducing Mito-CII.


Expiry date of Mito-CII-Kit compounds (according to NeuroVive)

Before preparation:

  • 3 years in -80° C
  • 1 year in -20° C


Prepared:

  • In DMSO solution
  • at room temperature: 24 hours.
  • at -20° C: for weeks


CAS-Numbers:

  • NV-118: 1592635-33-0
  • NV-161: 1432752-62-9


Labels: MiParea: Instruments;methods 





HRR: O2k-Protocol 

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