OROBOROS INSTRUMENTS

»Oroboros Ecosystem«

Oroboros Ecosystem Agenda - 2020 week 38

2020 Week 38

Sep-14 Mo

World Mitochondrial Disease Week – Sep 13-19

World Mitochondrial Disease Week raises awareness of mitochondrial disease through educational, fundraising and advocacy activities.

See what is happening near you - »https://mitochondrialdiseaseweek.org/events/

Sep-15 Tu - World Lymphoma Awareness Day

OXPHOS as a potential therapeutic target in classical Hodgkin lymphoma

from the O2k-Network »DE Frankfurt Droese S«, »DE Frankfurt Wittig I« and »NL Nijmegen Brandt U«

Birkenmeier K, Droese S, Wittig I, Winkelmann R, Käfer V, Doering C, Hartmann S, Wenz T, Reichert AS, Brandt U, Hansmann ML (2016) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46. »Bioblast link«

Sep-16 We

Why are permeabilized muscle fibers (pfi) a poor sample type for studying reactive oxygen species (ROS) production?

In experiments with pfi, high oxygen concentrations are needed to avoid oxygen limitation. However, the high oxygen pressures used may artificially increase ROS, including H₂O₂ production, making pfi a less optimal model for ROS production studies.
- »Oxygen dependence of ROS production in pfi«
- communicated by »Komlodi Timea« and »Cardoso Luiza«

Sep-17 Th

Did you know that you can measure the respiratory activity available for phosphorylation of ADP to ATP in living cells?

SUIT protocols from the SUIT-003 family will guide you through the titrations needed to analyze free ROUTINE activity.
- »SUIT-003 O2 ce D009« and »SUIT-003 O2 ce-pce D020«
- communicated by »Cardoso Luiza« and »Komlodi Timea«

Sep-18 Fr

Sep-19 Sa

Sep-20 So

ESCI 2020 Virtual Event Sep 20-30

Oroboros of the month

Oroboros Sgrafitto

Another snapshot taken at Trogerhof, Tyrol, AT by Gnaiger Erich.

Symbolizing the ouroboros, an ancient symbol depicting a serpent or dragon eating its own tail.

Oroboros pictures of the month page

Yearly calendar - last update September 19, 2020

In focus

Bioblast alert 2020(13)

Some terms in “Mitochondrial physiology” Bioenergetics Communications 2020.1 (States and rates) did not look familiar ― what is the elementary unit [x]?

Fundamental answers, a critical discussion on the SI unit for count, and the meaning of Euclid’s unit and Euclid’s number are presented in an unusual ‘canonical review’:

Gnaiger Erich (2020) Canonical reviewer's comments on: Bureau International des Poids et Mesures (2019) The International System of Units (SI) 9th ed. MitoFit Preprint Arch 2020.4 doi:10.26124/mitofit:200004. - »Bioblast link«

Join the discussion on the MitoEAGLE Consortium Communication: “Mitochondrial physiology” Bioenergetics Communications 2020.1

» On a Comment in Nature Metabolism «

Stay alert

Bioblast alert 2020

MitoPedia alert - Currently Asked Questions

O2k-Publications alert

O2k-Open Support alert - Currently Asked Questions

Oroboros Agenda highlights

Funding acknowledgments

Next Oroboros Ecosystem Agenda 2020

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2020 Week 39

Sep-21 Mo - ESCI 2020 Virtual Event

12th ÖGMBT Annual Meeting 2020 Virtual Event Sep 21-23

- World Alzheimer's Day

Olive polyphenols prove promising in the protection against mitochondrial dysfunction due to Alzheimer's disease and brain aging

from the O2k-Network »DE Giessen Eckert GP«

Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248. »Bioblast link«

Resistance training effects in Alzheimer’s disease mouse model

from the O2k-Network »US FL Boca Raton Khamoui AV«

Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501. »Bioblast link«

Sep-22 Tu - 12th ÖGMBT Annual Meeting 2020 Virtual Event , ESCI 2020 Virtual Event

Did you know the reverse electron flow from Complex II to Complex I can be investigated in mitochondrial preparations by measuring hydrogen peroxide production using Amplex UltraRed assay?

The reverse electron flow, also called reverse electron transfer (RET), happens when electrons are transferred from Complex II to the Q-junction and then back to Complex I at high mt-membrane potential. This phenomenon results in high hydrogen peroxide production in some mitochondrial preparations. The SUIT-026 protocol was designed to investigate this effect.
- »SUIT-026«
- communicated by »Komlodi Timea« and »Cardoso Luiza«