Difference between revisions of "Glycerophosphate pathway control state"
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|abbr=Gp | |abbr=Gp | ||
|description=[[File:Gp.jpg|left|200px|Gp]] '''Gp''': The glycero-phosphate shuttle represents an important pathway, particularly in liver, of making cytoplasmic [[NADH]] available for mitochondrial [[oxidative phosphorylation]]. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophos-phate dehydrogenase. On the outer face of the inner mitochondrial membrane, mitochondrial glycerophosphate dehydrogenase oxidises glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein donates its reducing equivalents to the electron transfer system at the level of [[CoQ]]. | |description=[[File:Gp-shuttle.jpg|left|200px|Gp]] '''Gp''': The glycero-phosphate shuttle represents an important pathway, particularly in liver, of making cytoplasmic [[NADH]] available for mitochondrial [[oxidative phosphorylation]]. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophos-phate dehydrogenase. On the outer face of the inner mitochondrial membrane, mitochondrial glycerophosphate dehydrogenase oxidises glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein donates its reducing equivalents to the electron transfer system at the level of [[CoQ]]. | ||
|info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 4.4]] | |info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 4.4]] | ||
}} | }} | ||
Revision as of 19:06, 25 February 2016
- high-resolution terminology - matching measurements at high-resolution
Glycerophosphate pathway control state
Description
Gp: The glycero-phosphate shuttle represents an important pathway, particularly in liver, of making cytoplasmic NADH available for mitochondrial oxidative phosphorylation. Cytoplasmic NADH reacts with dihydroxyacetone phosphate catalyzed by cytoplasmic glycerophos-phate dehydrogenase. On the outer face of the inner mitochondrial membrane, mitochondrial glycerophosphate dehydrogenase oxidises glycerophosphate back to dihydroxyacetone phosphate, a reaction not generating NADH but reducing a flavin prosthesic group. The reduced flavoprotein donates its reducing equivalents to the electron transfer system at the level of CoQ.
Abbreviation: Gp
Reference: Gnaiger 2014 MitoPathways - Chapter 4.4
MitoPedia O2k and high-resolution respirometry: "SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
SUIT state"SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
Gp(L)
Gp(P)
Gp(E)
Details
- Glycerophosphate oxidation is 10-fold higher in rabbit gracilis mitochondria (fast-twitch white muscle; 99% type IIb) compared to soleus (slow-twitch red muscle; 98% type I). Activity is comparatively low in human vastus lateralis. Glycerophosphate is an important substrate for respiration in brown adipose tissue mitochondria.
