Agarwal 2019 BMJ

From Bioblast
Publications in the MiPMap
Agarwal A, Ioannidis JPA (2019) PREDIMED trial of Mediterranean diet: retracted, republished, still trusted? BMJ 364:l341.

Β» PMID: 30733217

Agarwal A, Ioannidis JPA (2019) BMJ

Abstract: The PrevenciΓ³n con Dieta MediterrΓ‘nea (PREDIMED) trial1 is one of the most influential randomised trials ever. It was cited 3364 times in Google Scholar in the five years after its publication. However, in June 2018 the trial was retracted and republished because serious protocol deviations were detected. Moreover, the repercussions of these protocol deviations and of the correction process raise many additional important questions. How do you correct one of the most influential trials and the large universe of its secondary publications?

β€’ Bioblast editor: Gnaiger E

Selected quotes

  • The original PREDIMED publication1 had 18 authors and 223 collaborators. Many secondary papers also feature impressive numbers of coauthors. However, studies with hundreds of investigators may still have blind spots where no one really is responsible or knowledgeable enough to avert major mistakes and protocol deviations (box 2).
  • Competing interests: .. JPAI loves olive oil, nuts, and the Mediterranean diet.

Labels: MiParea: Exercise physiology;nutrition;life style  Pathology: Cardiovascular 

Ambiguity crisis, Gentle Science 

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