Arden 2015 Webvision

From Bioblast
Publications in the MiPMap
Arden GB, Ramsey DJ (2015) Diabetic retinopathy and a novel treatment based on the biophysics of rod photoreceptors and dark adaptation. In: Kolb H, Fernandez E, Nelson R, eds. Webvision: The organization of the retina and visual system [Internet]. Salt Lake City (UT): University of Utah Health Sciences Center; 1995-. Available from:

Β» Available from:

Arden GB, Ramsey DJ (2015) Webvision

Abstract: There is a pandemic of diabetes. More than 350 million people are affected world-wide. In the UK more than 4.2 million people (6.3 % of the population) are estimated to be living with diabetes, many without even knowing it (1). In the USA 29.1 million (9.3% of the population) have diabetes (2). Most individuals have type-2 diabetes, the onset of which is nearly universally attributed to the adoption of a β€œwestern diet”, rich in calories from refined carbohydrates and saturated fat. But type 1 diabetes is also increasing. Furthermore, type 2 diabetes now appears at much earlier ages, even in children, and increasing numbers of people with type-2 are insulin dependent (3). Individuals are not only developing diabetes at earlier ages, but also living longer. There are now various ways of controlling diabetes, but sadly these are not as successful in treating the complications of diabetes that are related to the heart, major blood vessels, peripheral nerves, kidneys and the eye (4). With an estimated 150,000 people in the UK developing diabetes each year, the prevalence of very long standing diabetes is growing even more rapidly than the prevalence of diabetes itself. This sets up a β€˜perfect storm’ for the complications of diabetes which develop after long periods.

β€’ Bioblast editor: Gnaiger E

Brownlee 2001 Nature CORRECTION.png

Figure 8 was reproduced from Brownlee 2001 Nature

Correction: FADH2 and Complex II

Ambiguity alert.png
FADH2 is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2024).
Gnaiger E (2024) Complex II ambiguities ― FADH2 in the electron transfer system. J Biol Chem 300:105470. - Β»Bioblast linkΒ«

Labels: Pathology: Diabetes 


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