| Name | Auwerx Johan, Prof. Dr. |
|---|---|
| Institution | Laboratory of Integrative & Systems Physiology (LISP)
Nestle Chair in Energy Metabolism (NCEM) Ecole Polytechnique Federale de Lausanne (EPFL) |
| Address | SV/IBI1/LISP/NCEM, Station 15, CH-1015 |
| City | Lausanne |
| State/Province | |
| Country | Switzerland |
| admin.auwerx@epfl.ch | |
| Weblink | http://auwerx-lab.epfl.ch |
| O2k-Network Lab | CH Lausanne Auwerx J |
Labels:
Field of research: Basic
Publications
| Published | Reference | |
|---|---|---|
| Oliveira 2023 J Biol Chem | 2023 | Oliveira AG, Oliveira LD, Cruz MV, Guimar茫es DSPSF, Lima TI, BC Santos-F谩vero, Luchessi AD, BA Pauletti, Leme AP, Bajgelman MC, Afonso J, Regitano LCA, Carvalho HF, Carneiro EM, Kobarg J, Perissi V, Auwerx J, Silveira LR (2023) Interaction between poly-A binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response. https://doi.org/10.1016/j.jbc.2023.104702 |
| Bresciani 2022 J Hepatol | 2022 | Bresciani N, Demagny H, Lemos V, Pontanari F, Li X, Sun Y, Li H, Perino A, Auwerx J, Schoonjans K (2022) The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. https://doi.org/10.1016/j.jhep.2022.05.040 |
| Zanou 2021 Nat Commun | 2021 | Zanou N, Dridi H, Reiken S, Imamura de Lima T, Donnelly C, De Marchi U, Ferrini M, Vidal J, Sittenfeld L, Feige JN, Garcia-Roves PM, Lopez-Mejia IC, Marks AR, Auwerx J, Kayser B, Place N (2021) Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity. Nat Commun 12:7219. |
| Rocha 2020 Sci Adv | 2020 | Rocha AL, de Lima TI, de Souza GP, Corr锚a RO, Ferrucci DL, Rodrigues B, Lopes-Ramos C, Nilsson D, Knittel TL, Castro PR, Fernandes MF, Dos Santos Martins F, Parmigiani RB, Silveira LR, Carvalho HF, Auwerx J, Vinolo MAR, Boucher J, Mori MA (2020) Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression. Sci Adv 6:eabc6250. |
| Remie 2020 Am J Clin Nutr | 2020 | Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts SABM, Lutgens E, Schomakers BV, Elfrink HL, Zapata-P茅rez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P (2020) Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr 112:413-26. |
| D'Amico 2019 Mol Cell | 2019 | D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J (2019) The RNA-binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging. Mol Cell 73:775-87. |
| Vatner 2018 Aging Cell | 2018 | Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF (2018) Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. Aging Cell 17:e12751. |
| Ruiz 2017 Brain Pathol | 2017 | Ruiz M, B茅gou M, Launay N, Ranea-Robles P, Bianchi P, L贸pez-Erauskin J, Morat贸 L, Guilera C, Petit B, Vaurs-Barriere C, Gu茅ret-Gonthier C, Bonnet-Dupeyron MN, Fourcade S, Auwerx J, Boespflug-Tanguy O, Pujol A (2017) Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease. Brain Pathol 28:611-30. |
| Wang 2017 Mol Cell | 2017 | Wang X, Auwerx J (2017) Systems phytohormone responses to mitochondrial proteotoxic stress. Mol Cell 68:540-51. |
| Greggio 2017 Cell Metab | 2017 | Greggio C, Jha P, Kulkarni SS, Lagarrigue S, Broskey NT, Boutant M, Wang X, Alonso SC, Ofori E, Auwerx J, Cant贸 C, Amati F (2017) Enhanced respiratory chain supercomplex formation in response to exercise in human skeletal muscle. Cell Metab 25:301-11. |
| Sadhukhan 2016 Proc Natl Acad Sci U S A | 2016 | Sadhukhan S, Liu X, Ryu D, Nelson OD, Stupinski JA, Li Z, Chen W, Zhang S, Weiss RS, Locasale JW, Auwerx J, Lin H (2016) Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proc Natl Acad Sci U S A 113:4320-5. |
| Quiros 2016 Nat Rev Mol Cell Biol | 2016 | Quiros PM, Mottis A, Auwerx J (2016) Mitonuclear communication in homeostasis and stress. Nat Rev Mol Cell Biol 17:213-26. |
| Gariani 2016 J Hepatol | 2016 | Gariani K, Ryu D, Menzies KJ, Yi HS, Stein S, Zhang H, Perino A, Lemos V, Katsyuba E, Jha P, Vijgen S, Rubbia-Brandt L, Kim YK, Kim JT, Kim KS, Shong M, Schoonjans K, Auwerx J (2016) Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease. J Hepatol 66:132-41. |
| Williams 2016 Science | 2016 | Williams EG, Wu Y, Jha P, Dubuis S, Blattmann P, Argmann CA, Houten SM, Amariuta T, Wolski W, Zamboni N, Aebersold R, Auwerx J (2016) Systems proteomics of liver mitochondria function. Science 352 (6291):aad0189. |
| Koopman 2016 Nat Protoc | 2016 | Koopman M, Michels H, Dancy BM, Kamble R, Mouchiroud L, Auwerx J, Nollen EA, Houtkooper RH (2016) A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans. Nat Protoc 11:1798-816. |
| Gariani 2016 Hepatology | 2016 | Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku SC, Koo SI, Fomitchova A, Cant贸 C, Schoonjans K, Sauve AA, Lee JY, Auwerx J (2016) Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease. Hepatology 63:1190-204. |
| Van de Weijer 2015 Diabetes | 2015 | van de Weijer T, Phielix E, Bilet L, Williams EG, Ropelle ER, Bierwagen A, Livingstone R, Nowotny P, Sparks LM, Paglialunga S, Szendroedi J, Havekes B, Moullan N, Pirinen E, Hwang JH, Schrauwen-Hinderling VB, Hesselink MK, Auwerx J, Roden M, Schrauwen P (2015) Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans. Diabetes 64:1193-201. |
| Bonhoure 2015 Genes Dev | 2015 | Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC Jr, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM1 (2015) Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Genes Dev 29:934-47. |
| Ryu 2014 Cell Metab | 2014 | Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J (2014) A SIRT7-dependent acetylation switch of GABP尾1 controls mitochondrial function. Cell Metab 20:856-69. |
| Timmers 2011 Cell Metab | 2011 | Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MK, Kunz I, Schrauwen-Hinderling VB, Blaak EE, Auwerx J, Schrauwen P (2011) Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 14:612-22. |
| Canto 2009 Nature | 2009 | Cant贸 AC, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458:1056-60. |
Abstracts
| Published | Reference | |
|---|---|---|
| Bouitbir 2012 Abstract IOC68 | 2012 | Bouitbir J, Charles A-L, Echaniz-Laguna A, Kindo M, Daussin F, Auwerx J, Piquard F, Geny B, Zoll J (2012) Effects of statins on mitochondrial function in cardiac and skeletal muscles. MiPNet17.08. |
