Avram 2021 Life (Basel)

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Publications in the MiPMap
Avram VF, Bina AM, Sima A, Aburel OM, Sturza A, Burlacu O, Timar RZ, Muntean DM, Elmer E, Cretu OM (2021) Improvement of platelet respiration by cell-permeable succinate in diabetic patients treated with statins. Life (Basel) 11:288.

» PMID: 33800630 Open Access

Avram Vlad Florian, Bina Anca Mihaela, Sima Alexandra, Aburel Oana Maria, Sturza Adrian, Burlacu Ovidiu, Timar Romulus Zorin, Muntean Danina Mirela, Elmer Eskil, Cretu Octavian Marius (2021) Life (Basel)

Abstract: Diabetes mellitus (DM) is the most severe metabolic disease that reached the level of a global pandemic and is associated with high cardiovascular morbidity. Statins are the first-line lipid-lowering therapy in diabetic patients with or without a history of atherosclerotic disease. Although well tolerated, chronic treatment may result in side effects that lead to treatment interruption. Mitochondrial dysfunction has emerged as a central pathomechanism in DM- and statin-induced side effects. Assessment of mitochondrial respiration in peripheral platelets has been increasingly used as a mirror of organ mitochondrial dysfunction. The present study aimed to assess the: (i) changes in mitochondrial respiration elicited by statins in patients with type 2 DM and (ii) the effects of cell-permeable succinate (NV118) on respiratory parameters in platelets harvested from these patients. No significant changes were found in global mitochondrial respiration of intact platelets isolated from diabetic patients treated with either atorvastatin or rosuvastatin. Similarly, no significant changes in mitochondrial respiration of permeabilized platelets were found between diabetic patients treated with atorvastatin and healthy controls. Acute ex vivo administration of NV118 significantly improved respiration in isolated platelets. These results prompt further research on the role of permeable succinate as a therapeutic alternative for improving mitochondrial function in metabolic pathologies and point to the role of peripheral platelets as a potential biomarker of treatment response. Keywords: Cell–permeable succinate (NV118), Diabetes, High–resolution respirometry, Mitochondria, Platelets, Statins Bioblast editor: Reiswig R O2k-Network Lab: RO Timisoara Muntean DM, SE Lund Elmer E


Labels: MiParea: Respiration, Patients, Pharmacology;toxicology  Pathology: Diabetes 

Organism: Human  Tissue;cell: Platelet  Preparation: Permeabilized cells, Intact cells 


Coupling state: LEAK, ROUTINE, OXPHOS, ET  Pathway: N, S, NS, ROX  HRR: Oxygraph-2k 

2021-08