Blier 2013 Abstract MiP2013
|Blier PU, Lemieux H, Pichaud N (2013) Holding our breath in our modern world: are mitochondria keeping the pace with global changes? Mitochondr Physiol Network 18.08.|
Changes in environmental temperature can pose significant challenges to animals. Shifts in thermal habitat have been shown to be a major force driving species adaptation. These adaptations have been the focus of major research efforts to delineate the physiological or metabolic constraints related to temperature and to reveal the phenotypic characters that can or should adjust. Considering the current consensus on climate change, the focus of research will likely move on questioning if they will survive to future modifications of their thermal niches. Adjustments to temperature can either be through physiological plasticity (e.g. acclimation) or via genetic adaptation. Therefore we will have to specify what are the genetic and phenotypic attributes (at the level of individual, population and species) that could grant survival success. These questions are particularly important for ectotherms, which are in thermal equilibrium with the surrounding environment. To start answering these queries, we should wonder if any physiological or metabolic function set the temperature impact on organisms. Some recent developments point to mitochondria as a key metabolic structure that partly delineates the thermal range that organism can tolerate . The catalytic capacity of mitochondria is highly sensitive to thermal variation and therefore should partly dictate the temperature dependence of biological functions. Mitochondria are a complex network of pathways of different enzymatic reactions that synergistically interact. The fine regulation of both ATP and ROS production depends on this integration of different enzymes and pathways. Here, we will scrutinize the temperature dependence of different parts of the mitochondrial pathways and evaluate the evolutionary challenges that should be overcome to insure mitochondrial adaptations to new thermal environments.
Labels: MiParea: Respiration, Comparative MiP;environmental MiP
Organism: Other invertebrates
Regulation: Temperature Coupling state: OXPHOS
1 - Laboratoire de physiologie integrative, Dépt de Biologie Université du Québec, Canada;
2 - Campus Saint-Jean, University of Alberta, Edmonton, Canada.
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