Calabria 2014 Abstract IOC96

From Bioblast
Calabria E (2014) High-intensity interval training (HIT) in aging: changes in cardiovascular fitness and cardiometabolic risk factors. Mitochondr Physiol Network 19.11.


Calabria E, Bruseghini P, Tam E, Pogliaghi S, Milanese C, Schena F, Capelli C (2014)

Event: IOC96

High Intensity Interval Training (HIT) has been shown to improve cardiovascular fitness and seems to induce beneficial modifications of cardiometabolic risk factors in healthy subjects and patients. Less is known about the efficacy of HIT applied to healthy older adults, and the adaptations induced at the central and periprheral level.

This study tested the hypothesis that 8 weeks of HIT can induce significant improvements of cardiovascular fitness, exercise capacity and of selected cardiometabolic risk factors in healthy older adults. In 12 healthy elderly male volunteers, we measured V’O2max, gas exchange threshold (GET ), respiratory compensation point (RCP), resting mean, systolic and diastolic blood pressures (MBP, SDP, DBP), fasting blood glucose concentration (GLU), total cholesterol/HDL ratio (CHOLtot/HDL), % body fat (BF) and waist circumference (WC) before (PRE) and after (POST) an 8-week of HIT. The training program consisted of 7 bouts of 2-min near-maximal cycling (i.e. 85-90%V’O2max) interspersed with 2 minutes of recovery performed 3 times a week.

Absolute and relative V’O significantly increased by 5.4 % and 11.7 % respectively. V’O at GET and RCP increased by 7.2 % respectively. MBP and SDP significantly decreased by 7 % and 9 % respectively. GLU was diminished by 7 % and TC/HDL decreased by 5 %. BF and WC decreased by 4 % and 1.4 % respectively. Surprisingly, analysis of the quadriceps muscle showed that both CSA and muscle volume significantly increased (5.0 and 5.4% respectively). Thus we can conclude that 8 weeks of HIT promote significant changes of maximal aerobic power and exercise resistance in healthy, male, elderly subjects. In addition, they induce significant improvements of some selected cardiometabolic risk factors.

Further studies are now needed to investigate how peripheral modifications in the skeletal muscle tissue may contribute to the described adaptations. Changes in the mass and/or in the function of the mitochondrial network will be evaluated on skeletal muscle biopsies in association to the assessment of muscle fiber type expression and capillary density.

β€’ O2k-Network Lab: IT Verona Calabria E

Labels: MiParea: Exercise physiology;nutrition;life style, Patients  Pathology: Aging;senescence 

Organism: Human  Tissue;cell: Skeletal muscle 



Dept Neurological and Movement Sc, Univ Verona

Cookies help us deliver our services. By using our services, you agree to our use of cookies.