Falcao-Tebas 2020 J Physiol

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Publications in the MiPMap
FalcΓ£o-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol 598:4251-70.

Β» PMID: 32539156

Falcao-Tebas Filippe, Marin Evelyn C, Kuang Jujiao, Bishop David J, McConell Glenn K (2020) J Physiol

Abstract: We investigated whether maternal exercise before and during gestation could attenuate the negative metabolic effects of paternal high-fat diet-induced obesity in female adult rat offspring. Fathers consumed a normal chow or high-fat diet (42% energy as fat) before mating. Mothers exercised on a treadmill before and during gestation or remained sedentary. In adulthood, female offspring were assessed using intraperitoneal insulin and glucose tolerance tests (IPITT and IPGTT, respectively), pancreatic morphology, ex vivo skeletal muscle insulin-stimulated glucose uptake, and mitochondrial respiratory function. Paternal obesity impaired whole-body and skeletal muscle insulin sensitivity and insulin secretion in adult offspring. Maternal exercise attenuated the lower insulin-stimulated glucose uptake in offspring sired by obese fathers but distal insulin signalling components (p-AKT Thr308 and Ser473, p-TBC1D4 Thr642 and GLUT4) remained unchanged (P > 0.05). Maternal exercise increased citrate synthase activity only in offspring sired by obese fathers. Maternal exercise also reversed the lower insulin secretion in vivo observed in offspring of obese fathers, likely due to an attenuation of the decrease in pancreatic beta cell mass. In summary, maternal exercise before and during pregnancy in rats attenuated skeletal muscle insulin resistance and attenuated the decrease in pancreatic beta cell mass and insulin secretion observed in the female offspring of obese fathers. This article is protected by copyright. All rights reserved. β€’ Keywords: Developmental origins of health and disease (DOHaD), Gestation, High-fat diet, Mitochondria, Pancreas, Physical activity, Pregnancy, Signalling, Skeletal muscle β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: AU Melbourne Bishop DJ

Labels: MiParea: Respiration, Developmental biology, Exercise physiology;nutrition;life style  Pathology: Obesity 

Organism: Rat  Tissue;cell: Skeletal muscle  Preparation: Permeabilized tissue 

Coupling state: LEAK, OXPHOS, ET  Pathway: N, NS, ROX  HRR: Oxygraph-2k, O2k-Fluorometer 

2020-06, AmR 

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