Flatters 2015 Prog Mol Biol Transl Sci

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Flatters SJ (2015) The contribution of mitochondria to sensory processing and pain. Prog Mol Biol Transl Sci 131:119-46.

» PMID:25744672

Flatters SJ (2015) Prog Mol Biol Transl Sci

Abstract: Mitochondria have a variety of essential functions within neurons including oxygen consumption, ATP generation, calcium buffering, and reactive oxygen species (ROS) generation. Despite extensive research into the contribution of mitochondrial function in other neurological disorders such as Parkinson's disease, the role of mitochondrial function in sensory processing and pain has been relatively unexplored until recent years. As this area of pain research is in its infancy, this review will be a descriptive summary-rather than a critical review-of data that suggests mitochondrial function/dysfunction as a causal or contributory mechanism of normal sensory processing and chronic pain. Evidence for mitochondrial dysfunction from both chronic pain patients and animal models of chronic pain will be described. Such evidence involves different aspects of mitochondria and their function including mitochondrial ultrastructure, distribution, oxygen consumption, oxidative phosphorylation, calcium buffering, ROS, and ATP levels. Most recently, substantial amounts of data have demonstrated mitochondrial involvement in painful peripheral neuropathies evoked by chemotherapy, diabetes, and HIV and these topics will be particularly highlighted in this review.

Keywords: Calcium buffering, Chemotherapy-induced neuropathy, DRG, Diabetic neuropathy, HIV-associated neuropathy, Mitochondria, Mitochondrial bioenergetics, Neuron, Pain, ROS


Labels: MiParea: Respiration, mt-Medicine  Pathology: Diabetes, Other 

Organism: Rat  Tissue;cell: Nervous system  Preparation: Homogenate, Isolated mitochondria  Enzyme: Complex I, Complex IV;cytochrome c oxidase, Complex V;ATP synthase 

Coupling state: OXPHOS, ET  Pathway: N, S, CIV, NS  HRR: Oxygraph-2k