Garcia JA

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O2k-Network Lab


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Publications

 PublishedReference
Doerrier 2016 Mitochondrion2016Doerrier C, García JA, Volt H, Díaz-Casado ME, Luna-Sánchez M, Fernández-Gil B, Escames G, López LC, Acuña-Castroviejo D (2016) Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network. Mitochondrion 27:56-63.
Volt 2016 J Pineal Res2016Volt H, García JA, Doerrier C, Díaz-Casado ME, Guerra-Librero A, López LC, Escames G, Tresguerres JA, Acuña-Castroviejo D (2016) Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin. J Pineal Res 60:193-205.
Garcia 2015 FASEB J2015García JA, Volt H, Venegas C, Doerrier C, Escames G, López LC, Acuña-Castroviejo D (2015) Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice. FASEB J 29:3863-75.
Ortiz 2015 J Pineal Res2015Ortiz F, Acuña-Castroviejo D, Doerrier C, Dayoub JC, López LC, Venegas C, García JA, López A, Volt H, Luna-Sánchez M, Escames G (2015) Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis. J Pineal Res 58:34-49.
Ortiz 2014 J Pineal Res2014Ortiz F, García JA, Acuña-Castroviejo D, Doerrier C, López A, Venegas C, Volt H, Luna-Sánchez M, López LC, Escames G (2014) The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS. J Pineal Res 56:71-81.
Doerrier 2014 Life Sci2014Doerrier C, García JA, Volt H, Díaz-Casado ME, Lima-Cabello E, Ortiz F, Luna-Sánchez M, Escames G, López LC, Acuña-Castroviejo D (2014) Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry. Life Sci 121:158-65.
Garcia-Corzo 2013 Hum Mol Genet2013García-Corzo L, Luna-Sánchez M, Doerrier C, García JA, Guarás A, Acín-Pérez R, Bullejos-Peregrín J, López A, Escames G, Enríquez JA, Acuña-Castroviejo D, López LC (2013) Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency. Hum Mol Genet 22:1233-48.
Acuña-Castroviejo 2011 Curr Top Med Chem2011Acuña-Castroviejo D; López LC; Escames G; López A; García JA; Reiter RJ (2011) Melatonin-mitochondria interplay in health and disease. Curr Top Med Chem 11:221-240.
Lopez 2009 J Pineal Res2009López A, García JA, Escames G, Venegas C, Ortiz F, López LC, Acuña-Castroviejo D (2009) Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production. J Pineal Res 46:188-98.

Abstracts

 PublishedReference
Volt 2014 Abstract SECF2014Experimental basis for the “inflammaging” theory.
Garcia 2014 Abstract SECF2014Melatonin disrupts the NF-κB/NLRP3 connection in sepsis through RORα receptor.
Diaz-Casado 2014 Abstract SECF2014Melatonin restores mitochondrial regulatory gene expression and function in the zebrafish model of parkinsonism.
Volt 2014 Abstract The 2014 Ageing Summit2014Effects of melatonin on the age-dependent dysregulation of the Nf-Kb/Nlrp3 activation during sepsis.
Doerrier 2014 Abstract SECF2014Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice.
Luna-Sánchez 2014 Abstract SECF2014Mitochondrial encephalopathy due to coenzyme q deficiency: pathogenesis and treatment.
Doerrier 2012 Abstract Bioblast2012Doerrier C, Garcia JA, Escames G, Acuna-Castroviejo D (2012) Treatment with melatonin prevents myocardial mitochondrial dysfunction in experimental sepsis in mice. Mitochondr Physiol Network 17.12.