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The hexokinase catalyzes the phosphorylation of D-glucose at position 6 by ATP to yield D-glucose 6-phosphate as well as the phosphorylation of many other hexoses like D-fructose, D-mannose, D-glucosamine.

Abbreviation: HK

MitoPedia topics: Enzyme 

Glucose is unique in that it can be used to produce ATP by all cells in both the presence and absence of molecular oxygen (O2). The first step in glycolysis is the phosphorylation of glucose by hexokinase is a priming step in which the neutral D-glucose molecule is mobilized and made ready for the subsequent steps by its phosphorylation to a negatively charged molecule at the expense of ATP.

Hexokinase has a higher affinity for aldohexoses than for ketohexoses.