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Ma 2022 Int J Obes (Lond)

From Bioblast
Publications in the MiPMap
Ma H, He C, Li L, Gao P, Lu Z, Hu Y, Wang L, Zhao Y, Cao T, Cui Y, Zheng H, Yang G, Yan Z, Liu D, Zhu Z (2022) TRPC5 deletion in the central amygdala antagonizes high-fat diet-induced obesity by increasing sympathetic innervation.

Β» Int J Obes (Lond) 46:1544-55. PMID: 35589963

Ma Huan,  He Chengkang,  Li Li,  Gao Peng,  Lu Zongshi,  Hu Yingru,  Wang Lijuan,  Zhao Yu,  Cao Tingbing, Cui Yuanting, Zheng Hongting,  Yang Gangyi, Yan Zhencheng, Liu Daoyan, Zhu Zhiming (2022) Int J Obes (Lond)

Abstract: Transient receptor potential channel 5 (TRPC5) is predominantly distributed in the brain, especially in the central amygdala (CeA), which is closely associated with pain and addiction. Although mounting evidence indicates that the CeA is related to energy homeostasis, the possible regulatory effect of TRPC5 in the CeA on metabolism remains unclear. Here, we reported that the expression of TRPC5 in the CeA of mice was increased under a high-fat diet (HFD). Specifically, the deleted TRPC5 protein in the CeA of mice using adeno-associated virus resisted HFD-induced weight gain, accompanied by increased food intake. Furthermore, the energy expenditure of CeA-specific TRPC5 deletion mice (TRPC5 KO) was elevated due to augmented white adipose tissue (WAT) browning and brown adipose tissue (BAT) activity. Mechanistically, deficiency of TRPC5 in the CeA boosted nonshivering thermogenesis under cold stimulation by stimulating sympathetic nerves, as the Ξ²3-adrenoceptor (Adrb3) antagonist SR59230A blocked the effect of TRPC5 KO on this process. In summary, TRPC5 deletion in the CeA alleviated the metabolic deterioration of mice fed a HFD, and these phenotypic improvements were correlated with the increased sympathetic distribution and activity of adipose tissue.

β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: CN Chongqing Zhu Z

Labels: MiParea: Respiration, Genetic knockout;overexpression  Pathology: Obesity 

Organism: Mouse  Tissue;cell: Fat  Preparation: Isolated mitochondria 

HRR: Oxygraph-2k 

CN, 2022-11