Mitchell 1967 Nature
|Mitchell P (1967) Proton current flow in mitochondrial systems. Nature 214:1327–8.|
Abstract: Following recent publications in Nature on hydrogen ion concentrations and flows in mitochondria [1–5], Baum  (see preceding communication) has aptly drawn attention to the fact that the chemiosmotic hypothesis does not require a significant pH-difference across the mitochondrial membrane system . In the original outline of the hypothesis  it was shown that the major component of the protonmotive force (p.m.f.) should be a membrane potential. Admitting therefore that the experimental facts may be consistent with the driving of adenosine triphosphate (ATP) synthesis by a proton current that flows through the reversible ATPase system in the cristae membrane under a mainly electrical p.m.f., Baum  has asked how the very small number of free protons in the inner aqueous phase of a mitochondrion or sub-mitochondrial particle can permit the flow of an effective proton current, and whether there may not be special energetic obstacles to proton translocation in such small systems.
• Bioblast editor: Gnaiger E
- Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2:112 pp. doi:10.26124/bec:2020-0002
Labels: MiParea: Respiration
Preparation: Isolated mitochondria