Proline dehydrogenase (ProDH), L-proline:quinone oxidoreductase, is located on the inner side of the mtIM, oxidizing proline to delta-1-pyrroline-5-carboxylate, with reduction of FAD to FADH2 and direct entry into the Q-junction, exerting an additive effect of convergent pathways. ProDH is widely distributed in a variety of organisms, is a source of ROS, and may play a role in carcinogenesis.
Reference: Teulier 2016 Proc Biol Sci, Kononczuk et al 2015, Soares 2015 PLoS One
MitoPedia topics: Enzyme
Communicated by Garcia-Souza LF and Gnaiger E 2019-04-29
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