Scandalis 2019 Abstract IOC141

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Scandalis LM, Kramer P, Nelson B, Dozier S, Stone J, Kitzman D, Molina AJA (2019) Oxygen consumption of skeletal muscle in heart failure with preserved ejection fraction. Mitochondr Physiol Network 24.02.

Link: IOC141

Scandalis LM, Kramer P, Nelson B, Dozier S, Stone J, Kitzman D, Molina AJA (2019)

Event: IOC141

Heart failure with preserved left ventricular ejection fraction (HFpEF) is the most prevalent form of heart failure (HF) and is nearly unique to older adults, particularly older women. This disorder manifests as severe exercise intolerance as evidenced by significantly reduced peak exercise oxygen uptake (peak VO2). Previous studies indicate that, in addition to underlying cardiac dysfunction, ‘non-cardiac’ factors contribute to this reduction in exercise tolerance.

Several lines of evidence indicate that older adults with HFpEF have altered skeletal muscle metabolism. We have previously reported that older HFpEF patients have abnormal skeletal muscle oxygen utilization, mitochondrial content, and oxidative capacity compared to healthy controls. The relationships of these mitochondrial parameters with measures of exercise capacity indicate that these deficits may contribute to impaired skeletal muscle aerobic metabolism and severely reduced exercise tolerance in patients with HFpEF. In the current study, we examine skeletal muscle mitochondrial bioenergetics in patients with HFpEF. We obtained Vastus lateralis biopsies from 33 patients with HFpEF and 44 healthy controls. High resolution respirometry of permeabilized skeletal muscle fiber bundles revealed significantly lower oxygen consumption rates across states, including respiration driven by complex 1, complex 2, and MAX ETS.


Bioblast editor: Plangger M O2k-Network Lab: US CA San Diego Molina AJA


Labels: MiParea: Respiration, Exercise physiology;nutrition;life style  Pathology: Cardiovascular 

Organism: Human  Tissue;cell: Skeletal muscle  Preparation: Permeabilized tissue 


Coupling state: ET  Pathway: N, S  HRR: Oxygraph-2k 


Affiliations

Scandalis LM(1), Kramer P(2), Nelson B(3), Dozier S(1), Stone J(2), Kitzman D(4), Molina AJA(1)
  1. Div Geriatrics Gerontology, Univ California, San Diego
  2. Wake Forest School Medicine, Internal Medicine - Gerontology
  3. Internal Medicine - Cardiovascular, Wake Forest Baptist Health
  4. Cardiology, Depart Internal Medicine, Wake Forest School Medicine; Winston-Salem, NA; USA