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• Letts 2015 Curr Opin Struct Biol
  ...s JA, Sazanov LA (2015) Gaining mass: the structure of respiratory complex I-from bacterial towards mitochondrial versions. Curr Opin Struct Biol 33:135 ...a ∼3.8 Å resolution X-ray crystallographic study of mitochondrial complex I from yeast Yarrowia lipotytica. In this review we will discuss what we have
  1 KB (161 words) - 20:07, 6 November 2023
• Hinchliffe 2005 Science
  ...anov LA (2005) Organization of iron-sulfur clusters in respiratory complex I. Science 309:771-4. https://doi.org/10.1126/science.1113988 ...for the interpretation of the large amounts of data accumulated on complex I.
  1 KB (165 words) - 20:08, 6 November 2023
• Brandt 2013 Angew Chem Int Ed Engl
  ...nner workings: The X-ray crystal structure of the entire bacterial complex I at 3.3 Å resolution offers fascinating insights into a giant 536 kDa molec |enzymes=Complex I
  848 bytes (121 words) - 10:27, 4 November 2023
• Galemou Yoga 2020 Biochim Biophys Acta Bioenerg
  ...alemou Yoga E, Angerer H, Parey K, Zickermann V (2020) Respiratory complex I - Mechanistic insights and advances in structure determination. https://doi ...ress in structure determination and functional characterization of complex I and discuss current mechanistic models.
  2 KB (207 words) - 16:55, 22 March 2023
• Galemou Yoga 2021 Front Chem
  ...chiller J, Zickermann V (2021) Ubiquinone binding and reduction by complex I-open questions and mechanistic implications. https://doi.org/10.3389/fchem. ...tively. We here review the current knowledge on the interaction of complex I with Q and discuss recent hypothetical models for the coupling mechanism.
  2 KB (216 words) - 16:15, 22 March 2023
• Hunte 2010 Science
  ...s and structural basis of conformational coupling in mitochondrial complex I. https://doi.org/10.1126/science.1191046 ...ere, we report an x-ray crystallographic analysis of mitochondrial complex I. The positions of all iron-sulfur clusters relative to the membrane arm wer
  1 KB (176 words) - 14:10, 29 March 2023
• Sazanov 2023 Biochem J
  ...mechanism: what have we learned from the structures of respiratory complex I. Biochem J 480:319-33. https://doi.org/10.1042/BCJ20210285 ...s of complex I. In this review I discuss the state of knowledge on complex I, including the current most controversial issues.
  2 KB (274 words) - 20:04, 6 November 2023
• Zickermann 2015 Science
  ...5) Mechanistic insight from the crystal structure of mitochondrial complex I. https://doi.org/10.1126/science.1259859 ...nerative disorders. We report the x-ray structure of mitochondrial complex I at a resolution of 3.6 to 3.9 angstroms, describing in detail the central s
  2 KB (219 words) - 14:06, 28 March 2023
• Kmita 2015 Proc Natl Acad Sci U S A
  ...a Zn-binding site and is essential for biogenesis of mitochondrial complex I. https://doi.org/10.1073/pnas.1424353112 ...UMM gene or mutation of Zn-binding residues blocked a late step of complex I assembly. An accumulating assembly intermediate lacked accessory subunit N7
  2 KB (250 words) - 16:30, 27 March 2023
• Warne 2015 J Biol Chem
  ...Puentes Fabiola, Kip Maarten, Hilditch Laura, Walker Paul, Simone Michela I, Chan AW Edith, Towers Greg J, Coker Alun R, Duchen Michael R, Szabadkai Gy ...ibitor, JW47, using a quinolinium cation tethered to cyclosporine (CsA). X-ray analysis was used to validate the design concept and biological evaluation
  3 KB (349 words) - 20:10, 7 March 2020
• Olgar 2017 MiP2017
  ...sup> ([Ca²⁺]_i) and Zn²⁺ [Zn²⁺]i in cells from 24-month-old rats were about 5-fold higher than those of cell ...increases in both [Ca²⁺]_i and [Zn²⁺]_i, which can in turn contribute to mechanical dysfunction of the heart.
  3 KB (492 words) - 09:57, 3 October 2017
• Boerma 2015 Radiat Res
  ...a decline in cardiac function and an increase in plasma levels of troponin-I, while no such changes were observed in ''Gsta4''-null mice. Radiation-indu
  2 KB (303 words) - 15:35, 7 November 2016
• Noone 2023 J Physiol
  ...miot A, Kenny H, Chery I, Zahariev A, Normand S, Crampes F, de Glisezinski I, Rochfort KD, Laurens C, Bareille MP, Simon C, Bergouignan A, Blanc S, O'Go ...up> ; 33.50 ± 8.541 years; n = 10). Indirect calorimetry and dual-energy x-ray absorptiometry were used for measures of energy expenditure, exercise capac
  3 KB (412 words) - 17:42, 13 December 2023
• Iverson 2013 Biochim Biophys Acta
  |abstract=Over a decade has passed since the elucidation of the first X-ray crystal structure of any complex II homolog. In the intervening time, the s ::::* .. electrons enter the electron transport chain through either complex I or complex II. Complex II bridges the processes of oxidative phosphorylatio
  3 KB (362 words) - 15:41, 1 April 2023
• Indian Academy of Pediatrics Growth Charts Committee 2015 Indian Pediatr
  ...Cherian A, Goyal JP, Khadilkar A, Kumaravel V, Mohan V, Narayanappa D, Ray I, Yewale V (2015) Revised IAP growth charts for height, weight and body mass ...Cherian A, Goyal JP, Khadilkar A, Kumaravel V, Mohan V, Narayanappa D, Ray I, Yewale V
  5 KB (831 words) - 22:51, 8 March 2020
• Vidimce 2021 Front Pharmacol
  ...er a 17-day period. 2) Body composition was determined using dual-energy X-ray absorptiometry and by measuring organ and skeletal muscle masses. 3) Mitoch ...rubinemic rats demonstrated increased flux control ratio (FCR) via complex I and II (CI+II) (Gunn: 0.78 ± 0.16 vs. Control: 0.62 ± 0.09, ''p'' < 0.05)
  4 KB (474 words) - 11:23, 8 July 2021
• Diaz 2023 Front Mol Biosci
  ...ifically, RCR was lowest among children with HBP and low aerobic capacity (i.e., mean peak ˙''V''O2 -1SD). HOMA2-IR did not associate with measures of
  3 KB (384 words) - 15:17, 5 October 2023
• Ortiz 2013 Abstract SEOR
  ...rials and methods. Male Wistar rats were subjected to irradiation with a X-ray YXLON Y.Tu 320-D03 irradiator, and the animals received a dose of 7.5 Gy/da ...pical gel melatonin. Melatonin decreases the expression of NF-kB, iNOS/i-mtNOS, NLRP3, ASC, caspase-1, and proinflammatory cytokines. Melaton
  3 KB (409 words) - 00:58, 10 February 2020
• Watmough 2010 Biochim Biophys Acta
  ...nt mitochondrial flavoprotein dehydrogenases to the ubiquinone pool. The X-ray structure of the pig liver enzyme has been solved in the presence and absen ...rom carbohydrate and ketone body (β-hydroxybutyrate) oxidation via complex I of the main respiratory chain [10]. This potential for cross-talk may provi
  3 KB (483 words) - 08:17, 13 September 2023
• Kenny 2017 Diabetologia
  ...ne insulin sensitivity, and body composition was assessed by dual-energy x-ray absorptiometry (DEXA). |enzymes=Complex I, Complex II;succinate dehydrogenase, Complex III, Complex V;ATP synthase
  3 KB (472 words) - 10:31, 16 August 2018

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