Tiebe 2019 Sci Rep

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Tiebe M, Lutz M, Senyilmaz Tiebe D, Teleman AA (2019) Crebl2 regulates cell metabolism in muscle and liver cells. Sci Rep 9:19869.

» PMID: 31882710 Open Access

Tiebe M, Lutz M, Senyilmaz Tiebe D, Teleman AA (2019) Sci Rep

Abstract: We previously identified Drosophila REPTOR and REPTOR-BP as transcription factors downstream of mTORC1 that play an important role in regulating organismal metabolism. We study here the mammalian ortholog of REPTOR-BP, Crebl2. We find that Crebl2 mediates part of the transcriptional induction caused by mTORC1 inhibition. In C2C12 myoblasts, Crebl2 knockdown leads to elevated glucose uptake, elevated glycolysis as observed by lactate secretion, and elevated triglyceride biosynthesis. In Hepa1-6 hepatoma cells, Crebl2 knockdown also leads to elevated triglyceride levels. In sum, this works identifies Crebl2 as a regulator of cellular metabolism that can link nutrient sensing via mTORC1 to the metabolic response of cells.


Bioblast editor: Plangger M O2k-Network Lab: DE Heidelberg Teleman A


Labels: MiParea: Respiration, nDNA;cell genetics, Genetic knockout;overexpression 


Organism: Mouse  Tissue;cell: Skeletal muscle, Liver  Preparation: Permeabilized cells, Intact cells 


Coupling state: LEAK, ROUTINE, OXPHOS  Pathway: F, N, Gp, ROX  HRR: Oxygraph-2k 

Labels, 2020-01