Xhani 2017 Thesis
|Xhani M (2017) Cellular redox homeostasis and environmental toxicity. Dissertation p110.|
Abstract: The first one who described the biological relevance of the ‘homeostasis’, as coined by Walter Bradford Cannon in 1926, was Claude Bernard in the 19th century, when he described the protective stability properties for the tissues and organs of the interstitial fluid. He used the term ‘mileu intérieur’ whose fine equilibria, if broken bring to pathology. The causes that can break cellular homeostasis can be physical, chemical or biological which, under normal conditions, induce feedback reactions to restore the physiological equilibrium. If the stimulus is persistent, however, there can be an alteration of homeostasis. This is how, commonly, the oxidative stress occurs, with a breakage of the physiologic cell redox steady state leading to alteration of its homeostasis. Potentially harming circumstances which may challenge redox homeostasis in a way or another are variations of the O2 concentration in the aerobic life, as well as interaction with other living systems or exposure to different xenobiotics. ...
Labels: MiParea: Respiration, Comparative MiP;environmental MiP, Pharmacology;toxicology Pathology: Cancer
Organism: Human Tissue;cell: Liver, Other cell lines Preparation: Permeabilized cells
Coupling state: OXPHOS Pathway: N, S, CIV, ROX HRR: Oxygraph-2k