Difference between revisions of "Arya 2012 Cytokine"
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{{Publication | {{Publication | ||
|title= | |title=Arya AK, Pokharia D, Bhan S, Tripathi R, Tripathi K (2012) Correlation between IL-7 and MCP-1 in diabetic chronic non healing ulcer patients at higher risk of coronary artery disease. Cytokine 60:767-71. | ||
|info=http://www. | |info=[http://www.ncbi.nlm.nih.gov/pubmed/22921903 PMID: 22921903] | ||
|authors= | |authors=Arya AK, Pokharia D, Bhan S, Tripathi R, Tripathi K | ||
|year=2012 | |year=2012 | ||
|journal=Cytokine | |journal=Cytokine | ||
|abstract=Cytokines play an extremely important role in the pathogenesis of coronary artery disease (CAD) in which interleukin (IL)-7 is a major regulator of T-cell homeostasis which is conced in the stimulation of leukocyte–endothelial cell adhesion during inflammatory events. Circulating IL-7 is associated with activation of monocyte and natural killer cells, leading to enhanced production of inflammatory cytokines and chemokines observed in atherosclerosis and acute coronary syndromes. Plasma levels of IL-7, hs-CRP and monocyte chemoattractant protein (MCP)-1 were measured by an immunoenzymatic ELISA technique. Ninety neuropathic diabetic foot patients were divided into two groups: group B [those without CAD (n = 45)] and group C [those with higher risk of CAD (n = 45)]. Thirty-five healthy subjects were included as control (group H). Plasma concentration of IL-7, MCP-1 and hs-CRP were significantly higher in group C as compare with group H and B. Plasma IL-7 levels also showed significant positive correlations with plasma levels of hs-CRP and MCP-1. Abnormalities in lipid profile were also observed. In conclusion the positive correlation between plasma concentration of IL-7, MCP-1 and hs-CRP in diabetic foot patients observed herein, suggests a plausible role for IL-7 in the promotion of clinical instability in coronary artery disease. | |abstract=Cytokines play an extremely important role in the pathogenesis of coronary artery disease (CAD) in which interleukin (IL)-7 is a major regulator of T-cell homeostasis which is conced in the stimulation of leukocyte–endothelial cell adhesion during inflammatory events. Circulating IL-7 is associated with activation of monocyte and natural killer cells, leading to enhanced production of inflammatory cytokines and chemokines observed in atherosclerosis and acute coronary syndromes. Plasma levels of IL-7, hs-CRP and monocyte chemoattractant protein (MCP)-1 were measured by an immunoenzymatic ELISA technique. Ninety neuropathic diabetic foot patients were divided into two groups: group B [those without CAD (''n'' = 45)] and group C [those with higher risk of CAD (''n'' = 45)]. Thirty-five healthy subjects were included as control (group H). Plasma concentration of IL-7, MCP-1 and hs-CRP were significantly higher in group C as compare with group H and B. Plasma IL-7 levels also showed significant positive correlations with plasma levels of hs-CRP and MCP-1. Abnormalities in lipid profile were also observed. In conclusion the positive correlation between plasma concentration of IL-7, MCP-1 and hs-CRP in diabetic foot patients observed herein, suggests a plausible role for IL-7 in the promotion of clinical instability in coronary artery disease. | ||
Highlights | Highlights | ||
► Diabetic foot patients are at higher risk of coronary artery disease (CAD). ► IL-7, MCP-1 and hs-CRP promotes clinical instability towards CAD. ► IL-7 up regulating the expression of MCP-1; induces inflammatory processes. ► Abnormalities in lipid profile of diabetic foot patients shows higher risk of CAD. | |||
Abbreviations | Abbreviations | ||
T2DM, type 2 diabetes mellitus; SBP, systolic blood pressure; DBP, diastolic blood pressure; CAD, coronary artery disease; IL, interleukin; MCP, monocyte chemoattractant protein; hsCRP, high sensitive C-reactive protein | |||
|keywords=Interleukin, Diabetes mellitus, Neuropathy, Diabetic foot, Coronary artery disease | |||
|keywords=Interleukin | |||
}} | }} | ||
{{Labeling | {{Labeling | ||
Revision as of 10:12, 23 October 2015
| Arya AK, Pokharia D, Bhan S, Tripathi R, Tripathi K (2012) Correlation between IL-7 and MCP-1 in diabetic chronic non healing ulcer patients at higher risk of coronary artery disease. Cytokine 60:767-71. |
Arya AK, Pokharia D, Bhan S, Tripathi R, Tripathi K (2012) Cytokine
Abstract: Cytokines play an extremely important role in the pathogenesis of coronary artery disease (CAD) in which interleukin (IL)-7 is a major regulator of T-cell homeostasis which is conced in the stimulation of leukocyte–endothelial cell adhesion during inflammatory events. Circulating IL-7 is associated with activation of monocyte and natural killer cells, leading to enhanced production of inflammatory cytokines and chemokines observed in atherosclerosis and acute coronary syndromes. Plasma levels of IL-7, hs-CRP and monocyte chemoattractant protein (MCP)-1 were measured by an immunoenzymatic ELISA technique. Ninety neuropathic diabetic foot patients were divided into two groups: group B [those without CAD (n = 45)] and group C [those with higher risk of CAD (n = 45)]. Thirty-five healthy subjects were included as control (group H). Plasma concentration of IL-7, MCP-1 and hs-CRP were significantly higher in group C as compare with group H and B. Plasma IL-7 levels also showed significant positive correlations with plasma levels of hs-CRP and MCP-1. Abnormalities in lipid profile were also observed. In conclusion the positive correlation between plasma concentration of IL-7, MCP-1 and hs-CRP in diabetic foot patients observed herein, suggests a plausible role for IL-7 in the promotion of clinical instability in coronary artery disease.
Highlights ► Diabetic foot patients are at higher risk of coronary artery disease (CAD). ► IL-7, MCP-1 and hs-CRP promotes clinical instability towards CAD. ► IL-7 up regulating the expression of MCP-1; induces inflammatory processes. ► Abnormalities in lipid profile of diabetic foot patients shows higher risk of CAD.
Abbreviations T2DM, type 2 diabetes mellitus; SBP, systolic blood pressure; DBP, diastolic blood pressure; CAD, coronary artery disease; IL, interleukin; MCP, monocyte chemoattractant protein; hsCRP, high sensitive C-reactive protein • Keywords: Interleukin, Diabetes mellitus, Neuropathy, Diabetic foot, Coronary artery disease
Labels: MiParea: Exercise physiology;nutrition;life style, Patients
Organism: Human
Tissue;cell: Blood cells
