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Difference between revisions of "Chance 1955 J Biol Chem-III"

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{{Labeling
{{Labeling
|organism=Rat, Guinea pig
|tissues=Hepatocyte; Liver
|tissues=Hepatocyte; Liver
|preparations=Isolated Mitochondria
|preparations=Isolated Mitochondria

Revision as of 10:38, 13 February 2013

Publications in the MiPMap
Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation: III. The steady state. J Biol Chem 217: 409-427.

Β» PMID: 13271404 Open Access

Chance B, Williams GR (1955) J Biol Chem

Abstract: In a complex enzymatic sequence the site of action of substrates and inhibitors is clearly marked by the way they affect the steady state concentrations of the components of the system. Antimycin A, for example, inhibits respiration in the succinic oxidase system and at the same time increases the steady state reduction of cytochrome b and decreases that of cytochromes c, a, and aa3. In the oxidative phosphorylation system of liver mitochondria, phosphate and phosphate acceptors cause a considerable activation of respiration and may do so by a reversal of inhibitory reactions along the respiratory chain. Thus measurements of changes in the steady state of the members of the respiratory chain upon initiation and cessation of oxidative phosphorylation of ADP may identify sites in the chain where the phosphorylation reactions occur. β€’ Keywords: Respiratory enzymes, Respiratory chain, Steady state, OXPHOS, Liver mitochondria


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Organism: Rat, Guinea pig  Tissue;cell: Hepatocyte; Liver"Hepatocyte; Liver" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property.  Preparation: Isolated Mitochondria"Isolated Mitochondria" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property. 


Coupling state: LEAK, OXPHOS 


Made history 

Definition of States 1 to 5