Difference between revisions of "Charles 2020 Nanomedicine (Lond)"
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{{Publication | {{Publication | ||
|title=Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) | |title=Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) 15:2917-32. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/33241963 PMID: 33241963] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/33241963 PMID: 33241963] | ||
|authors=Charles | |authors=Charles Carleigh, Cohen-Erez Ifat, Kazaoka Blake, Melnikov Olga, Stein David E, Sensenig Richard, Rapaport Hanna, Orynbayeva Zulfiya | ||
|year=2020 | |year=2020 | ||
|journal=Nanomedicine (Lond) | |journal=Nanomedicine (Lond) | ||
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|keywords=OxPhos, TPP+, Cancer, Ionidamine, Membrane potential, Mitochondria, Nanoparticles | |keywords=OxPhos, TPP+, Cancer, Ionidamine, Membrane potential, Mitochondria, Nanoparticles | ||
|editor=[[Plangger M]] | |editor=[[Plangger M]] | ||
|mipnetlab=US PA Philadelphia Orynbayeva Z | |||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area=Respiration | |area=Respiration, mt-Structure;fission;fusion, Pharmacology;toxicology | ||
|instruments=Oxygraph-2k | |organism=Human | ||
|additional=2020-12 | |tissues=Endothelial;epithelial;mesothelial cell | ||
|preparations=Isolated mitochondria | |||
|topics=mt-Membrane potential | |||
|couplingstates=LEAK, OXPHOS | |||
|pathways=N, S, CIV, ROX | |||
|instruments=Oxygraph-2k, O2k-Fluorometer, TPP | |||
|additional=2020-12, AmR | |||
}} | }} |
Latest revision as of 15:48, 19 October 2021
Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) 15:2917-32. |
Charles Carleigh, Cohen-Erez Ifat, Kazaoka Blake, Melnikov Olga, Stein David E, Sensenig Richard, Rapaport Hanna, Orynbayeva Zulfiya (2020) Nanomedicine (Lond)
Abstract: The mechanistic study of the drug carrier-target interactions of mitochondria-unique nanoparticles composed of polypeptide-peptide complexes (mPoP-NPs).
The isolated organelles were employed to address the direct effects of mPoP-NPs on dynamic structure and functional wellbeing of mitochondria. Mitochondria morphology, respiration, membrane potential, reactive oxygen species generation, were examined by confocal microscopy, flow cytometry and oxygraphy. Lonidamine-encapsulated formulation was assessed to evaluate the drug delivery capacity of the naive nanoparticles.
The mPoP-NPs do not alter mitochondria structure and performance upon docking to organelles, while successfully delivering drug that causes organelle dysfunction.
The study gives insight into interactions of mPoP-NPs with mitochondria and provides substantial support for consideration of designed nanoparticles as biocompatible and efficient mitochondria-targeted platforms. β’ Keywords: OxPhos, TPP+, Cancer, Ionidamine, Membrane potential, Mitochondria, Nanoparticles β’ Bioblast editor: Plangger M β’ O2k-Network Lab: US PA Philadelphia Orynbayeva Z
Labels: MiParea: Respiration, mt-Structure;fission;fusion, Pharmacology;toxicology
Organism: Human
Tissue;cell: Endothelial;epithelial;mesothelial cell
Preparation: Isolated mitochondria
Regulation: mt-Membrane potential Coupling state: LEAK, OXPHOS Pathway: N, S, CIV, ROX HRR: Oxygraph-2k, O2k-Fluorometer, TPP
2020-12, AmR