Difference between revisions of "Chinopoulos 2013 J Neurosci Res"
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|title=Chinopoulos C (2003) Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex.. Journal of | |title=Chinopoulos C (2003) Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex.. Journal of Neuroscience Research 91(8): 1030-43. | ||
|info=https://pubmed.ncbi.nlm.nih.gov/23378250/ | |info=https://pubmed.ncbi.nlm.nih.gov/23378250/ | ||
|authors=Chinopoulos C | |authors=Chinopoulos C | ||
Revision as of 10:28, 14 March 2022
| Chinopoulos C (2003) Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex.. Journal of Neuroscience Research 91(8): 1030-43. |
» https://pubmed.ncbi.nlm.nih.gov/23378250/
Chinopoulos C (2003) Journal of neuroscience research
Abstract: The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high-energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this Mini-Review, these segments are appraised, pointing to the critical importance of the α-ketoglutarate dehydrogenase complex dictating their directionalities. • Keywords: TCA cycle • Bioblast editor: Cardoso LHD • O2k-Network Lab: HU Budapest Chinopoulos C
Labels:
Stress:Hypoxia
