Chinopoulos 2013 J Neurosci Res
| Chinopoulos C (2013) Which way does the citric acid cycle turn during hypoxia? The critical role of Ξ±-ketoglutarate dehydrogenase complex. Journal of Neuroscience Research 91(8): 1030-43. |
Chinopoulos C (2013) J Neurosci Res
Abstract: The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high-energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this Mini-Review, these segments are appraised, pointing to the critical importance of the Ξ±-ketoglutarate dehydrogenase complex dictating their directionalities. β’ Keywords: TCA cycle β’ Bioblast editor: Cardoso LHD β’ O2k-Network Lab: HU Budapest Chinopoulos C
Labels:
Stress:Hypoxia
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