Clapham 2007 Cell
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| Clapham DE (2007) Calcium signaling. Cell 131(6):1047-58. |
Clapham David E (2007) Cell
Abstract: Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles. Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription.
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Regulation: Calcium
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