Difference between revisions of "Correa 2015 Critical Care Horizon"
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|title=Corrêa TD, Jakob SM, Takala J (2015) Mitochondrial function in sepsis. Critical Care Horizon 1:31-41 . | |title=Corrêa TD, Jakob SM, Takala J (2015) Mitochondrial function in sepsis. Critical Care Horizon 1:31-41 . | ||
|info=[ | |info=[http://www.criticalcarehorizons.com/wp-content/uploads/2040/06/mitochondrial-function-sepsis-FINAL.pdf Open Access PDF] | ||
|authors=Correa TD, Jakob SM, Takala J | |authors=Correa TD, Jakob SM, Takala J | ||
|year=2015 | |year=2015 | ||
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{{Labeling | {{Labeling | ||
|area=Respiration | |area=Respiration | ||
|organism=Pig | |||
|tissues=Liver | |||
|preparations=Isolated mitochondria | |||
|diseases=Sepsis | |diseases=Sepsis | ||
|couplingstates=LEAK | |couplingstates=LEAK, OXPHOS | ||
|substratestates=CI, CII, CIV, ROX | |substratestates=CI, CII, CIV, ROX | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional= | |additional=Review | ||
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Revision as of 13:11, 31 March 2016
| Corrêa TD, Jakob SM, Takala J (2015) Mitochondrial function in sepsis. Critical Care Horizon 1:31-41 . |
Correa TD, Jakob SM, Takala J (2015) Critical Care Horizon
Abstract: Sepsis syndrome represents a leading cause of intensive care unit (ICU) admission, morbidity and mortality. Several areas within the pathophysiology of sepsis remain controversial despite extensive pre-clinical and clinical research. It has been postulated that mitochondrial dysfunction may contribute to organ dysfunction and failure in sepsis. Nevertheless, many aspects of mitochondrial malfunction and the exact mechanisms as to how it may be linked to organ dysfunction remain unknown. Here, we briefly review some basic concepts of mitochondrial function in sepsis. The main available methods to assess mitochondrial function are presented and pre-clinical and clinical work summarized to show and explain some of the main controversies surrounding the role of mitochondrial function in sepsis. Finally, we propose future directions for new research in the field. • Keywords: Sepsis, Septic shock, Mitochondria, Multiple organ failure, Animal model, Resuscitation
Labels: MiParea: Respiration
Pathology: Sepsis
Organism: Pig Tissue;cell: Liver Preparation: Isolated mitochondria
Coupling state: LEAK, OXPHOS
HRR: Oxygraph-2k
Review
