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| {{MitoPedia | | {{MitoPedia |
| |abbr=''CCC'' | | |abbr= |
| |description='''Coupling control capacities''', ''CCC'', are [[flux control capacity|flux control capacities]], ''FCC'', at a constant mitochondrial [[substrate state]]. In mitochondrial preparations, there are three well-defined coupling states of respiration, ''L'', ''P'', ''E'' ([[LEAK]], [[OXPHOS]], [[ETS]]). In intact cells, state ''P'' cannot be induced, but a [[ROUTINE]] state of respiration, ''R'', can be measured. | | |description='''Coupling-control efficiencies''' are [[flux control efficiency |flux control efficiencies]] ''j<sub>Z-Y</sub>'' at a constant [[ET-pathway competent state]]. |
| | |info=[[Flux control efficiency]] |
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| 1. If the [[metabolic control variable]], ''X'', is an [[uncoupler]], the [[reference state]] ''Z'' is ''E''. Then two [[background state]]s, ''Y'', of coupling control are possible: The uncoupler may act on the ''L'' or ''P'' state in mt-preparations, and on the ''L'' or ''R'' state in intact cells. The corresponding coupling control capacities are:
| | == Compare == |
| * ''E-L'' coupling control capacity, Ξ''j<sub>E-L</sub>'' = (''E-L'')/''E'' = 1-''L/E'' (mt-preparations and intact cells)
| | ::::* [[Coupling-control ratio]] |
| * ''E-P'' coupling control capacity, Ξ''j<sub>E-P</sub>'' = (''E-P'')/''E'' = 1-''P/E'' (mt-preparations)
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| * ''E-P'' coupling control capacity, Ξ''j<sub>E-P</sub>'' = (''E-P'')/''E'' = 1-''P/E'' (intact cells) | |
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| 2. If the metablic control variable is stimulation by [[ADP]], D, or release of an inhibitor of DT-phosphorylation (e.g. -Omy), the reference state ''Z'' is ''P'' in mt-preparations at saturating [[ADP], or ''R'' in intact cells at physiologically controlled steady states of [[ADP]] and ATP-turnover.
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| or ''P'', and the such that the lower and upper limits of ''CCR'' are defined as 0.0 and 1.0. Then there are two mitochondrial ''CCR'', [[L/E|''L/E'']] and [[P/E|''P/E'']], and two ''CCR'' for intact cells, [[L/E|''L/E'']] and [[R/E|''R/E'']].
| | {{MitoPedia concepts |
| |info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Pesta 2012 Methods Mol Biol]] | | |mitopedia concept=Respiratory control ratio |
| }} | | }} |
| {{MitoPedia methods | | {{MitoPedia methods |
| |mitopedia method=Respirometry | | |mitopedia method=Respirometry |
| }} | | }} |
| {{MitoPedia topics
| | Β |
| |mitopedia topic=Respiratory control ratio
| | [[Category:Coupling control]] |
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| ==See also==
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| *[[UCR|Uncoupling control ratio, UCR]]
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| *Compare [[Respiratory acceptor control ratio]], RCR
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