Difference between revisions of "Coupling-control efficiency"

Revision as of 16:17, 3 June 2020

high-resolution terminology - matching measurements at high-resolution

Coupling-control efficiency

Description

Coupling control factors, CCF, are flux control factors, FCF, at a constant ET-pathway competent state.

Abbreviation: CCF

Reference: Flux control factor

MitoPedia concepts: Respiratory control ratio

MitoPedia methods: Respirometry

Compare

Coupling-control ratio

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 {{MitoPedia
-|abbr=''CCC''
+|abbr=''CCF''
-|description='''Coupling control capacities''', ''CCC'', are [[flux control capacity|flux control capacities]], ''FCC'', at a constant mitochondrial [[substrate state]]. In mitochondrial preparations, there are three well-defined coupling states of respiration, ''L'', ''P'', ''E'' ([[LEAK]], [[OXPHOS]], [[ETS]]). In intact cells, state ''P'' cannot be induced, but a [[ROUTINE]] state of respiration, ''R'', can be measured.
+|description='''Coupling control factors''', ''CCF'', are [[flux control factor]]s, ''FCF'', at a constant [[ET-pathway competent state]].
+|info=[[Flux control factor]]
-. If the [[metabolic control variable]], ''X'', is an [[uncoupler]], the [[reference state]] ''Z'' is ''E''. Then two [[background state]]s, ''Y'', of coupling control are possible: The uncoupler may act on the ''L'' or ''P'' state in mt-preparations, and on the ''L'' or ''R'' state in intact cells. The corresponding coupling control capacities are:
+}}
-* ''E-L'' coupling control capacity, Δ''j<sub>E-L</sub>'' = (''E-L'')/''E'' = 1-''L/E'' (mt-preparations and intact cells)
+{{MitoPedia concepts
-* ''E-P'' coupling control capacity, Δ''j<sub>E-P</sub>'' = (''E-P'')/''E'' = 1-''P/E'' (mt-preparations)
+|mitopedia concept=Respiratory control ratio
-* ''E-P'' coupling control capacity, Δ''j<sub>E-P</sub>'' = (''E-P'')/''E'' = 1-''P/E'' (intact cells)
-. If the metablic control variable is stimulation by [[ADP]], D, or release of an inhibitor of DT-phosphorylation (e.g. -Omy), the reference state ''Z'' is ''P'' in mt-preparations at saturating [[ADP], or ''R'' in intact cells at physiologically controlled steady states of [[ADP]] and ATP-turnover.
-or ''P'', and the such that the lower and upper limits of ''CCR'' are defined as 0.0 and 1.0. Then there are two mitochondrial ''CCR'', [[L/E|''L/E'']] and [[P/E|''P/E'']], and two ''CCR'' for intact cells, [[L/E|''L/E'']] and [[R/E|''R/E'']].
-|info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Pesta 2012 Methods Mol Biol]]
 }}
 {{MitoPedia methods
 |mitopedia method=Respirometry
 }}
-{{MitoPedia topics
+{{MitoPedia O2k and high-resolution respirometry}}
-|mitopedia topic=Respiratory control ratio
+{{MitoPedia topics}}
-}}
+== Compare ==
-==See also==
+* [[Coupling-control ratio]]
-*[[UCR|Uncoupling control ratio, UCR]]
+[[Category:Coupling control]]
-*Compare [[Respiratory acceptor control ratio]], RCR