Diaz-Casado 2014 Abstract SECF
| Melatonin restores mitochondrial regulatory gene expression and function
in the zebrafish model of parkinsonism. |
Link:
Díaz-Casado E, Lima-Cabello E, Doerrier C, García JA, Escames G, Acuña-Castroviejo D (2014)
Event: SECF
Parkinson’s disease (PD) is a neurological disorder characterized by the progressive loss of dopaminergic (DA) neurons. Oxidative stress and inflammation are two key processes in the pathophysiology of PD. Both mechanisms are directly related to mitochondrial dysfunction and bioenergetic failure, which promotes neuronal death. The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which specifically inhibits mitochondrial complex I activity, is usually used to yied parkinsonism in roedents and zebrafish. The association between mitochondrial dysfunction and neurodegeneration is gaining experimental support in PD, which can be associated with mutations in mitochondria-associated genes including DJ-1, alpha-synuclein, Park-2 and PINK-1. Because mitochondria are the main target of melatonin actions, we evaluated here whether its neuroprotective actions depend on the regulation of these genes in the zebrafish model of PD.
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