Dickinson 1967 Science
From Bioblast
| Dickinson DB, Misch MJ, Drury RE (1967) Dimethyl sulfoxide protects tightly coupled mitochondria from freezing damage. Science 156:1738-9. |
Dickinson DB, Misch MJ, Drury RE (1967) Science
Abstract: Dimethyl sulfoxide prevented loss of respiratory control and decrease in efficiency of oxidative phosphorylation when plant mitochondria were stored in liquid nitrogen. Respiration was severely inhibited and was not stimulated by adenosine diphosphate when mitochondria were frozen in liquid nitrogen without dimethyl sulfoxide. Thus, isolated mitochondria provide a model system for the study of the effects of freezing on biological membranes and of the prevention, by dimethyl sulfoxide, of freezing damage.
Labels: MiParea: Respiration
Stress:Cryopreservation
Preparation: Isolated mitochondria
Coupling state: LEAK, OXPHOS
