Difference between revisions of "Etomoxir"
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{{MitoPedia | {{MitoPedia | ||
|abbr=Eto | |abbr=Eto | ||
|description='''Etomoxir''' (Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of carnitine palmitoyltransferase | |description='''Etomoxir''' (Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of [[carnitine palmitoyltransferase I]] (CPT-I) on the outer face of the mitochondrial inner membrane. Eto inhibits [[fatty acid oxidation]] by blocking the formation of acyl carnitines from long-chain fatty acids which require the carnitine shuttle for transport into mitochondria. In contrast to long-chain fatty acids, the transport of short- and medium-chain fatty acids is carnitine-independent. | ||
|info= | |info= | ||
}} | }} | ||
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[[File:Etomoxir structure.png|right|300px|File:Etomoxir structure]] | [[File:Etomoxir structure.png|right|300px|File:Etomoxir structure]] | ||
'''Caution:''' Store tightly sealed, protected from exposure to light. Acute toxicity (oral, dermal, inhalation. Dust mask or eyeshields, faceshields and gloves are recommended by the preparation. | == Application in [[HRR]] == | ||
::: '''Eto (Etomoxir):''' ((+)-Etomoxir sodium salt hydrate); Sigma Aldrich; E-1905; storage: 2-8 °C; M = 338.76 g·mol<sup>-1</sup> | |||
:::: <span style="color:#8B008B">'''Caution:''' Store tightly sealed, protected from exposure to light. Acute toxicity (oral, dermal, inhalation). Dust mask or eyeshields, faceshields and gloves are recommended by the preparation.</span> | |||
'''Preparation of 10 mM | ::::'''Preparation of 10 mM stock solution''' (dissolved in H<sub>2</sub>O): The commercially available white compound is soluble in water. | ||
:: | ::::# Weigh 5 mg etomoxir. | ||
:: | ::::# Add 1.476 mL dt H<sub>2</sub>O. | ||
:: | ::::# Divide into 500 µL portions. | ||
:: | ::::# Store frozen at -20 °C. | ||
{{MitoPedia topics | |||
|mitopedia topic=Inhibitor | |||
}} | |||
{{Labeling | |||
|additional=MitoPedia:FAT4BRAIN | |||
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Latest revision as of 06:35, 20 April 2023
Description
Etomoxir (Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of carnitine palmitoyltransferase I (CPT-I) on the outer face of the mitochondrial inner membrane. Eto inhibits fatty acid oxidation by blocking the formation of acyl carnitines from long-chain fatty acids which require the carnitine shuttle for transport into mitochondria. In contrast to long-chain fatty acids, the transport of short- and medium-chain fatty acids is carnitine-independent.
Abbreviation: Eto
Application in HRR
- Eto (Etomoxir): ((+)-Etomoxir sodium salt hydrate); Sigma Aldrich; E-1905; storage: 2-8 °C; M = 338.76 g·mol-1
- Caution: Store tightly sealed, protected from exposure to light. Acute toxicity (oral, dermal, inhalation). Dust mask or eyeshields, faceshields and gloves are recommended by the preparation.
- Preparation of 10 mM stock solution (dissolved in H2O): The commercially available white compound is soluble in water.
- Weigh 5 mg etomoxir.
- Add 1.476 mL dt H2O.
- Divide into 500 µL portions.
- Store frozen at -20 °C.
MitoPedia topics: Inhibitor
Labels:
MitoPedia:FAT4BRAIN