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Etomoxir (Eto; 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate) is an irreversible inhibitor of carnitine palmitoyltransferase I (CPT-I) on the outer face of the mitochondrial inner membrane. Eto inhibits fatty acid oxidation by blocking the formation of acyl carnitines from long-chain fatty acids which require the carnitine shuttle for transport into mitochondria. In contrast to long-chain fatty acids, the transport of short- and medium-chain fatty acids is carnitine-independent.

Abbreviation: Eto

File:Etomoxir structure

Application in HRR

Eto (Etomoxir): ((+)-Etomoxir sodium salt hydrate); Sigma Aldrich; E-1905; storage: 2-8 Β°C; M = 338.76 gΒ·mol-1
Caution: Store tightly sealed, protected from exposure to light. Acute toxicity (oral, dermal, inhalation). Dust mask or eyeshields, faceshields and gloves are recommended by the preparation.
Preparation of 10 mM stock solution (dissolved in H2O): The commercially available white compound is soluble in water.
  1. Weigh 5 mg etomoxir.
  2. Add 1.476 mL dt H2O.
  3. Divide into 500 Β΅L portions.
  4. Store frozen at -20 Β°C.

MitoPedia topics: Inhibitor 



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