Difference between revisions of "Fernandez-Vizarra 2022 Cell Metab"
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{{Publication | {{Publication | ||
|title=FernĂĄndez-Vizarra E, LĂłpez-Calcerrada S, Sierra-Magro A, PĂ©rez-PĂ©rez R, Formosa LE, Hock DH, Illescas M, Peñas A, Brischigliaro M, Ding S, Fearnley IM, Tzoulis C, Pitceathly RDS, Arenas J, MartĂn MA, Stroud DA, Zeviani M, Ryan MT, Ugalde C (2022) Two independent respiratory chains adapt OXPHOS performance to glycolytic switch. https://doi.org/10.1016/j.cmet.2022.09.005 | |title=FernĂĄndez-Vizarra E, LĂłpez-Calcerrada S, Sierra-Magro A, PĂ©rez-PĂ©rez R, Formosa LE, Hock DH, Illescas M, Peñas A, Brischigliaro M, Ding S, Fearnley IM, Tzoulis C, Pitceathly RDS, Arenas J, MartĂn MA, Stroud DA, Zeviani M, Ryan MT, Ugalde C (2022) Two independent respiratory chains adapt OXPHOS performance to glycolytic switch. https://doi.org/10.1016/j.cmet.2022.09.005 | ||
|info=Cell Metab 34:1792-808.e6. [https://pubmed.ncbi.nlm.nih.gov/36198313 PMID: 36198313 | |info=Cell Metab 34:1792-808.e6. [https://pubmed.ncbi.nlm.nih.gov/36198313 PMID: 36198313] | ||
|authors=Fernandez-Vizarra Erika, Lopez-Calcerrada Sandra, Sierra-Magro Ana, Perez-Perez Rafael, Formosa Luke E, Hock Daniella H, Illescas Maria, Penas Ana, Brischigliaro Michele, Ding Shujing, Fearnley Ian M, Tzoulis Charalampos, Pitceathly Robert DS, Arenas Joaquin, Martin Miguel A, Stroud David A, Zeviani Massimo, Ryan Michael T, Ugalde Cristina | |authors=Fernandez-Vizarra Erika, Lopez-Calcerrada Sandra, Sierra-Magro Ana, Perez-Perez Rafael, Formosa Luke E, Hock Daniella H, Illescas Maria, Penas Ana, Brischigliaro Michele, Ding Shujing, Fearnley Ian M, Tzoulis Charalampos, Pitceathly Robert DS, Arenas Joaquin, Martin Miguel A, Stroud David A, Zeviani Massimo, Ryan Michael T, Ugalde Cristina | ||
|year=2022 | |year=2022 |
Latest revision as of 01:05, 10 April 2023
FernĂĄndez-Vizarra E, LĂłpez-Calcerrada S, Sierra-Magro A, PĂ©rez-PĂ©rez R, Formosa LE, Hock DH, Illescas M, Peñas A, Brischigliaro M, Ding S, Fearnley IM, Tzoulis C, Pitceathly RDS, Arenas J, MartĂn MA, Stroud DA, Zeviani M, Ryan MT, Ugalde C (2022) Two independent respiratory chains adapt OXPHOS performance to glycolytic switch. https://doi.org/10.1016/j.cmet.2022.09.005 |
» Cell Metab 34:1792-808.e6. PMID: 36198313
Fernandez-Vizarra Erika, Lopez-Calcerrada Sandra, Sierra-Magro Ana, Perez-Perez Rafael, Formosa Luke E, Hock Daniella H, Illescas Maria, Penas Ana, Brischigliaro Michele, Ding Shujing, Fearnley Ian M, Tzoulis Charalampos, Pitceathly Robert DS, Arenas Joaquin, Martin Miguel A, Stroud David A, Zeviani Massimo, Ryan Michael T, Ugalde Cristina (2022) Cell Metab
Abstract: The structural and functional organization of the mitochondrial respiratory chain (MRC) remains intensely debated. Here, we show the co-existence of two separate MRC organizations in human cells and postmitotic tissues, C-MRC and S-MRC, defined by the preferential expression of three COX7A subunit isoforms, COX7A1/2 and SCAFI (COX7A2L). COX7A isoforms promote the functional reorganization of distinct co-existing MRC structures to prevent metabolic exhaustion and MRC deficiency. Notably, prevalence of each MRC organization is reversibly regulated by the activation state of the pyruvate dehydrogenase complex (PDC). Under oxidative conditions, the C-MRC is bioenergetically more efficient, whereas the S-MRC preferentially maintains oxidative phosphorylation (OXPHOS) upon metabolic rewiring toward glycolysis. We show a link between the metabolic signatures converging at the PDC and the structural and functional organization of the MRC, challenging the widespread notion of the MRC as a single functional unit and concluding that its structural heterogeneity warrants optimal adaptation to metabolic function. âą Keywords: COX7A1â2, SCAFI/COX7RP/COX7A2L, Bioenergetics, Glycolysis, Metabolic switch, Mitochondria, Oxidative metabolism, Pyruvate dehydrogenase, Respiratory chain organizations, Respiratory supercomplexes âą Bioblast editor: Plangger M âą O2k-Network Lab: IT Padova Viscomi C
Labels: MiParea: Respiration, Genetic knockout;overexpression
Organism: Human
Tissue;cell: HEK
Preparation: Permeabilized cells, Intact cells
Enzyme: Supercomplex
Coupling state: LEAK, ET Pathway: N, S, Gp, NS, ROX HRR: Oxygraph-2k
2022-11