Difference between revisions of "Holian 1977 Arch Biochem Biophys"

Latest revision as of 12:45, 24 February 2015

Holian A, Owen CS, Wilson DF (1977) Control of Respiration in Isolated Mitochondria: Quantitative Evaluation of the Dependence of Respiratory Rates on [ATP], [ADP], and [Pi]. Arch Biochem Biophys 181:164-71.

» PMID:879801

Holian A, Owen CS, Wilson DF (1977) Arch Biochem Biophys

Abstract:

Labels: MiParea: Respiration

Preparation: Isolated mitochondria

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 {{Publication
-|title=Holian A, Owen CS, Wilson DF (1977) Control of Respiration in Isolated Mitochondria: Quantitative Evaluation of the Dependence of Respiratory Rates on [ATP], [ADP], and [Pi]. Arch Biochem Biophys 181:164-171.
+|title=Holian A, Owen CS, Wilson DF (1977) Control of Respiration in Isolated Mitochondria: Quantitative Evaluation of the Dependence of Respiratory Rates on [ATP], [ADP], and [Pi]. Arch Biochem Biophys 181:164-71.
 |info=[http://www.ncbi.nlm.nih.gov/pubmed/879801 PMID:879801]
 |authors=Holian A, Owen CS, Wilson DF
 |year=1977
 |journal=Arch Biochem Biophys
-|abstract=Mitochondrial preparations with respiratory control ratios greater than 10 have been
-isolated from dog and pigeon heart muscle. Suspensions of these mitochondria have been
-tested for the qualitative and quantitative dependence of the respiratory rate on the
-extramitochondrial ATP, ADP, and orthophosphate (Pi) concentrations. Reciprocal dependence
-is observed for [ATP] and [Pi] (the [ADP] required for a given rate of oxygen
-consumption is proportional to [ATP] and inversely proportional to [Pi]) which indicates
-that these two reactants are of equal importance in regulating the mitochondrial
-respiratory rate. Analysis of the [ATPI, [ADP], and [PJ in suspensions of mitochondria
-at various respiratory rates shows that the respiratory rate is proportional to the
-logarithm of the [ATP]/[ADP][PJ for values between lo3 and lo5 M-I. Similar results are
-obtained for suspensions of mitochondria prepared from rat brain, rat kidney, and rat
-liver. These data demonstrate that, in mitochondria with high respiratory control, the
-rate of respiration is dependent on extramitochondrial [ATPl/[ADPl[P,l and not on
-[ATP]/[ADP]. It is concluded that [P,]-independent adenine nucleotide translocation
-across the inner mitochondrial membrane is not a rate-limiting reaction in oxidative phosphorylation.
 }}
 {{Labeling
 |area=Respiration
-|organism=Dog
+|preparations=Isolated mitochondria
-|taxonomic group=Birds
-|preparations=Isolated Mitochondria
 }}