Jacobs 2013 J Appl Physiol: Difference between revisions
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Revision as of 17:40, 7 November 2016
Jacobs R, FlΓΌck D, Bonne TC, BΓΌrgi S, Christensen PM, Toigo M, Lundby C (2013) Improvements in exercise performance 1 with high-intensity interval training 2 coincide with an increase in skeletal muscle mitochondrial content and function. J Appl Physiol 115:785-93. |
Jacobs R, Flueck D, Bonne TC, Buergi S, Christensen PM, Toigo M, Lundby C (2013) J Appl Physiol
Abstract: Six sessions of high-intensity interval training (HIT) are sufficient to improve exercise capacity. The mechanisms explaining such improvements are unclear. Accordingly, the aim of this study was to perform a comprehensive evaluation of physiologically relevant adaptations occurring after six sessions of HIT to determine the mechanisms explaining improvements in exercise performance. Sixteen untrained (43 Β± 6 mlΒ·kg(-1)Β·min(-1)) subjects completed six sessions of repeated (8-12) 60 s intervals of high-intensity cycling (100% peak power output elicited during incremental maximal exercise test) intermixed with 75 s of recovery cycling at a low intensity (30 W) over a 2-wk period. Potential training-induced alterations in skeletal muscle respiratory capacity, mitochondrial content, skeletal muscle oxygenation, cardiac capacity, blood volumes, and peripheral fatigue resistance were all assessed prior to and again following training. Maximal measures of oxygen uptake (Vo2peak; βΌ8%; P = 0.026) and cycling time to complete a set amount of work (βΌ5%; P = 0.008) improved. Skeletal muscle respiratory capacities increased, most likely as a result of an expansion of skeletal muscle mitochondria (βΌ20%, P = 0.026), as assessed by cytochrome c oxidase activity. Skeletal muscle deoxygenation also increased while maximal cardiac output, total hemoglobin, plasma volume, total blood volume, and relative measures of peripheral fatigue resistance were all unaltered with training. These results suggest that increases in mitochondrial content following six HIT sessions may facilitate improvements in respiratory capacity and oxygen extraction, and ultimately are responsible for the improvements in maximal whole body exercise capacity and endurance performance in previously untrained individuals. β’ Keywords: HIT, Interval training, Mitochondria, Oxygen extraction, Sprint training
β’ O2k-Network Lab: CH Zurich Lundby C
Labels: MiParea: Respiration, mt-Biogenesis;mt-density, Exercise physiology;nutrition;life style
Organism: Human
Tissue;cell: Skeletal muscle
Preparation: Permeabilized tissue
Coupling state: LEAK, OXPHOS, ETS"ETS" is not in the list (LEAK, ROUTINE, OXPHOS, ET) of allowed values for the "Coupling states" property.
Pathway: F, N, S, CIV, NS, ROX
HRR: Oxygraph-2k