Khan 2015 Abstract MiPschool Cape Town 2015: Difference between revisions
No edit summary |
Bader Helga (talk | contribs) No edit summary |
||
Line 4: | Line 4: | ||
|year=2015 | |year=2015 | ||
|event=MiPschool Cape Town 2015 | |event=MiPschool Cape Town 2015 | ||
|abstract=Bioenergetic health index (BHI) profiling is an emerging concept in the field of mitochondrial research [1]. In general, bioenergetics is the study of balance between energy intake and energy utilization for life sustaining processes. Mitochondrion serves as an early warning signal of bioenergetics crisis in patient populations. Any changes in bioenergetics are the first signal to determine the progression of mitochondrial disorders that are complex and multifactorial. In order to achieve the above, the platelets from the patientβs blood samples were extracted and subjected to high throughput assays such as XF Extracellular Flux Analyzer, BHI can be calculated to represent the patientβs composite mitochondrial profile by monitoring the bioenergetic health of immune cells such as monocytes, lymphocytes, neutrophils and platelets from blood [2]. This approach can be a step towards personalized cell based measurements to quantify bioenergetic health index. The study will be discussed in detail later. Β | |abstract=Bioenergetic health index (BHI) profiling is an emerging concept in the field of mitochondrial research [1]. In general, bioenergetics is the study of balance between energy intake and energy utilization for life sustaining processes. Mitochondrion serves as an early warning signal of bioenergetics crisis in patient populations. Any changes in bioenergetics are the first signal to determine the progression of mitochondrial disorders that are complex and multifactorial. In order to achieve the above, the platelets from the patientβs blood samples were extracted and subjected to high throughput assays such as XF Extracellular Flux Analyzer, BHI can be calculated to represent the patientβs composite mitochondrial profile by monitoring the bioenergetic health of immune cells such as monocytes, lymphocytes, neutrophils and platelets from blood [2]. This approach can be a step towards personalized cell based measurements to quantify bioenergetic health index. The study will be discussed in detail later. | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
Line 10: | Line 10: | ||
|organism=Human | |organism=Human | ||
|tissues=Blood cells | |tissues=Blood cells | ||
|injuries=Mitochondrial | |injuries=Mitochondrial disease | ||
|additional=BHI | |additional=BHI | ||
}} | }} |
Revision as of 11:20, 23 February 2015
Bioenergetic Health Index profiling: step towards personalized medicine |
Link:
Khan N, van der Westerhuizen FH (2015)
Event: MiPschool Cape Town 2015
Bioenergetic health index (BHI) profiling is an emerging concept in the field of mitochondrial research [1]. In general, bioenergetics is the study of balance between energy intake and energy utilization for life sustaining processes. Mitochondrion serves as an early warning signal of bioenergetics crisis in patient populations. Any changes in bioenergetics are the first signal to determine the progression of mitochondrial disorders that are complex and multifactorial. In order to achieve the above, the platelets from the patientβs blood samples were extracted and subjected to high throughput assays such as XF Extracellular Flux Analyzer, BHI can be calculated to represent the patientβs composite mitochondrial profile by monitoring the bioenergetic health of immune cells such as monocytes, lymphocytes, neutrophils and platelets from blood [2]. This approach can be a step towards personalized cell based measurements to quantify bioenergetic health index. The study will be discussed in detail later.
Labels: MiParea: Patients
Stress:Mitochondrial disease Organism: Human Tissue;cell: Blood cells
BHI
Affiliations
Dept Biochem, North West Univ, South Africa. - Naaz.27khan@gmail.com
References
- Chacko BK, Kramer PA, Ravi S, Benavides GA, Mitchell T, Dranka BP, Ferrick D, Singal AK, Ballinger SW, Bailey SM, Hardy RW, Zhang J, Zhi D, Darley-Usmar VM (2014) The Bioenergetic Health Index: a new concept in mitochondrial translational research. Clin Sci 127:367-73.
- Kramer PA, Ravi S, Chacko B, Johnson MS, Darley-Usmar VM (2014) A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers. Redox Biol 10:206-10.