Kosenko 2010 Biology Bull
| Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biology Bull 37:346-50. |
Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) Biology Bull
Abstract: The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 ฮผg/ml with succinate, 60 ฮผg/ml with pyruvate or palmitoylcarnitine, and 120 ฮผg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen. โข Keywords: Hypoxen (Oliphen, Moscow)
Labels:
Organism: Rat
Tissue;cell: Liver
Preparation: Isolated mitochondria
HRR: Oxygraph-2k
Pharmacology; Biotechnology
