Difference between revisions of "Lefranc 2021 Int J Mol Sci"
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|title=Lefranc C, Friederich-Persson M, Foufelle F, Nguyen Dinh Cat A, Jaisser F (2021) Adipocyte-mineralocorticoid receptor alters mitochondrial quality control leading to mitochondrial dysfunction and senescence of visceral adipose tissue. Int J Mol Sci 22:2881. | |title=Lefranc C, Friederich-Persson M, Foufelle F, Nguyen Dinh Cat A, Jaisser F (2021) Adipocyte-mineralocorticoid receptor alters mitochondrial quality control leading to mitochondrial dysfunction and senescence of visceral adipose tissue. Int J Mol Sci 22:2881. | ||
|info=[https://pubmed.ncbi.nlm.nih.gov/33809055/ PMID: 33809055 Open Access] | |info=[https://pubmed.ncbi.nlm.nih.gov/33809055/ PMID: 33809055 Open Access] | ||
|authors=Clara | |authors=Lefranc Clara, Friederich-Persson Malou, Foufelle Fabienne, Nguyen Dinh Cat Aurelie, Jaisser Frederic | ||
|year=2021 | |year=2021 | ||
|journal=Int J Mol Sci | |journal=Int J Mol Sci | ||
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|keywords=Adipose tissue, Metabolic syndrome, Mineralocorticoid receptor, Mitochondrial dysfunction, Oxidative stress, Senescence | |keywords=Adipose tissue, Metabolic syndrome, Mineralocorticoid receptor, Mitochondrial dysfunction, Oxidative stress, Senescence | ||
|editor=[[Reiswig R]] | |editor=[[Reiswig R]] | ||
|mipnetlab=SE Uppsala Liss P | |||
}} | }} | ||
{{Labeling | {{Labeling | ||
Latest revision as of 11:09, 8 July 2021
| Lefranc C, Friederich-Persson M, Foufelle F, Nguyen Dinh Cat A, Jaisser F (2021) Adipocyte-mineralocorticoid receptor alters mitochondrial quality control leading to mitochondrial dysfunction and senescence of visceral adipose tissue. Int J Mol Sci 22:2881. |
Lefranc Clara, Friederich-Persson Malou, Foufelle Fabienne, Nguyen Dinh Cat Aurelie, Jaisser Frederic (2021) Int J Mol Sci
Abstract: Mineralocorticoid receptor (MR) expression is increased in the adipose tissue (AT) of obese patients and animals. We previously demonstrated that adipocyte-MR overexpression in mice (Adipo-MROE mice) is associated with metabolic alterations. Moreover, we showed that MR regulates mitochondrial dysfunction and cellular senescence in the visceral AT of obese db/db mice. Our hypothesis is that adipocyte-MR overactivation triggers mitochondrial dysfunction and cellular senescence, through increased mitochondrial oxidative stress (OS). Using the Adipo-MROE mice with conditional adipocyte-MR expression, we evaluated the specific effects of adipocyte-MR on global and mitochondrial OS, as well as on OS-induced damage. Mitochondrial function was assessed by high throughput respirometry. Molecular mechanisms were probed in AT focusing on mitochondrial quality control and senescence markers. Adipo-MROE mice exhibited increased mitochondrial OS and altered mitochondrial respiration, associated with reduced biogenesis and increased fission. This was associated with OS-induced DNA-damage and AT premature senescence. In conclusion, targeted adipocyte-MR overexpression leads to an imbalance in mitochondrial dynamics and regeneration, to mitochondrial dysfunction and to ageing in visceral AT. These data bring new insights into the MR-dependent AT dysfunction in obesity. • Keywords: Adipose tissue, Metabolic syndrome, Mineralocorticoid receptor, Mitochondrial dysfunction, Oxidative stress, Senescence • Bioblast editor: Reiswig R • O2k-Network Lab: SE Uppsala Liss P
Labels: MiParea: Respiration, Genetic knockout;overexpression
Pathology: Obesity
Organism: Mouse Tissue;cell: Fat Preparation: Isolated mitochondria
Coupling state: LEAK, OXPHOS, ET
Pathway: N
HRR: Oxygraph-2k
2021-07
