Li 2016 Neurochem Int: Difference between revisions
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{{Publication | {{Publication | ||
|title=Li H, Liu Y, Lin LT, Wang XR, Du SQ, Yan CQ, He T, Yang JW, Liu CZ ( | |title=Li H, Liu Y, Lin LT, Wang XR, Du SQ, Yan CQ, He T, Yang JW, Liu CZ (2016) Acupuncture reversed hippocampal mitochondrial dysfunction in vascular dementia rats. Neurochem Int 92:35-42. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/26682902 PMID: 26682902] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/26682902 PMID: 26682902] | ||
|authors=Li H, Liu Y, Lin LT, Wang XR, Du SQ, Yan CQ, He T, Yang JW, Liu CZ | |authors=Li H, Liu Y, Lin LT, Wang XR, Du SQ, Yan CQ, He T, Yang JW, Liu CZ | ||
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|organism=Rat | |organism=Rat | ||
|tissues=Nervous system | |tissues=Nervous system | ||
| | |preparations=Isolated mitochondria | ||
|diseases= | |enzymes=Complex I, Complex II;succinate dehydrogenase, Complex IV;cytochrome c oxidase | ||
|diseases=Neurodegenerative | |||
|couplingstates=LEAK, OXPHOS | |||
|pathways=S | |||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional= | |additional=2016-02 | ||
}} | }} |
Latest revision as of 12:09, 8 November 2016
Li H, Liu Y, Lin LT, Wang XR, Du SQ, Yan CQ, He T, Yang JW, Liu CZ (2016) Acupuncture reversed hippocampal mitochondrial dysfunction in vascular dementia rats. Neurochem Int 92:35-42. |
Li H, Liu Y, Lin LT, Wang XR, Du SQ, Yan CQ, He T, Yang JW, Liu CZ (2016) Neurochem Int
Abstract: Hippocampal mitochondrial dysfunction due to oxidative stress has been considered to play a major role in the pathogenesis of vascular dementia (VD). Previous studies suggested that acupuncture could improve cerebral hypoperfusion-induced cognitive impairments. However, whether hippocampal mitochondria are associated with this cognitive improvement remains unclear. In this study, an animal model of VD was established via bilateral common carotid arteries occlusion (BCCAO) to investigate the alterations of cognitive ability and hippocampal mitochondrial function. BCCAO rats showed impairments in hippocampal mitochondrial function, overproduction of reactive oxygen species (ROS) and learning and memory deficits. After two-week acupuncture treatment, BCCAO-induced spatial learning and memory impairments as shown in Morris water maze were ameliorated. Hippocampal mitochondrial respiratory complex enzymes (complex I, II, IV) activities and cytochrome c oxidase IV expression significantly increased, which might contribute to the reduction of hippocampal ROS generation. In addition, acupuncture significantly improved mitochondrial bioenergy parameters such as mitochondrial respiratory control rate and membrane potential not PDH A1 expression. Placebo-acupuncture did not produce similar therapeutic effects. These findings suggested that acupuncture reversed BCCAO-induced hippocampal mitochondrial dysfunction, which might contribute to its prevention on cognitive deficits. โข Keywords: Acupuncture, Hippocampus, Mitochondrial dysfunction, Vascular dementia
Labels: MiParea: Respiration
Pathology: Neurodegenerative
Organism: Rat Tissue;cell: Nervous system Preparation: Isolated mitochondria Enzyme: Complex I, Complex II;succinate dehydrogenase, Complex IV;cytochrome c oxidase
Coupling state: LEAK, OXPHOS Pathway: S HRR: Oxygraph-2k
2016-02