Difference between revisions of "Ling 2019 Cell Metab"
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{{Publication | {{Publication | ||
|title=Ling C, Rönn T (2019) Epigenetics in human obesity and type 2 diabetes. Cell Metab https://doi.org/10.1016/j.cmet.2019.03.009 | |title=Ling C, Rönn T (2019) Epigenetics in human obesity and type 2 diabetes. Cell Metab 29:1028-44. https://doi.org/10.1016/j.cmet.2019.03.009. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/30982733 PMID: 30982733 Open Access] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/30982733 PMID: 30982733 Open Access] | ||
|authors=Ling C, Roenn T | |authors=Ling C, Roenn T | ||
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|editor=[[Gnaiger E]], | |editor=[[Gnaiger E]], | ||
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== Cited by == | |||
{{Template:Cited by Gnaiger 2020 BEC MitoPhysiology}} | |||
{{Labeling | {{Labeling | ||
|area=mtDNA;mt-genetics, nDNA;cell genetics, Comparative MiP;environmental MiP, Gender, Exercise physiology;nutrition;life style, mt-Medicine | |area=mtDNA;mt-genetics, nDNA;cell genetics, Comparative MiP;environmental MiP, Gender, Exercise physiology;nutrition;life style, mt-Medicine | ||
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|organism=Human | |organism=Human | ||
|tissues=Skeletal muscle, Liver, Islet cell;pancreas;thymus, Blood cells, Fat | |tissues=Skeletal muscle, Liver, Islet cell;pancreas;thymus, Blood cells, Fat | ||
|additional=BEC 2020.1 | |||
}} | }} | ||
Latest revision as of 18:50, 16 January 2021
| Ling C, Rönn T (2019) Epigenetics in human obesity and type 2 diabetes. Cell Metab 29:1028-44. https://doi.org/10.1016/j.cmet.2019.03.009. |
Ling C, Roenn T (2019) Cell Metab
Abstract: Epigenetic mechanisms control gene activity and the development of an organism. The epigenome includes DNA methylation, histone modifications, and RNA-mediated processes, and disruption of this balance may cause several pathologies and contribute to obesity and type 2 diabetes (T2D). This Review summarizes epigenetic signatures obtained from human tissues of relevance for metabolism-i.e., adipose tissue, skeletal muscle, pancreatic islets, liver, and blood-in relation to obesity and T2D. Although this research field is still young, these comprehensive data support not only a role for epigenetics in disease development, but also epigenetic alterations as a response to disease. Genetic predisposition, as well as aging, contribute to epigenetic variability, and several environmental factors, including exercise and diet, further interact with the human epigenome. The reversible nature of epigenetic modifications holds promise for future therapeutic strategies in obesity and T2D.
Copyright © 2019 Elsevier Inc. All rights reserved.
• Bioblast editor: Gnaiger E
Cited by
- Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. doi:10.26124/bec:2020-0001.v1.
Labels: MiParea: mtDNA;mt-genetics, nDNA;cell genetics, Comparative MiP;environmental MiP, Gender, Exercise physiology;nutrition;life style, mt-Medicine
Pathology: Aging;senescence, Diabetes
Organism: Human Tissue;cell: Skeletal muscle, Liver, Islet cell;pancreas;thymus, Blood cells, Fat
BEC 2020.1
