Linley 2012 Proc Natl Acad Sci U S A: Difference between revisions
No edit summary |
No edit summary |
||
Line 2: | Line 2: | ||
|title=Linley JE, Ooi L, Pettinger L, Kirton H, Boyle JP, Chris Peers C, Gampera N (2012) Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons. Proc Natl Acad Sci U S A doi/10.1073/pnas.1201544109. | |title=Linley JE, Ooi L, Pettinger L, Kirton H, Boyle JP, Chris Peers C, Gampera N (2012) Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons. Proc Natl Acad Sci U S A doi/10.1073/pnas.1201544109. | ||
|info=[http://www.pnas.org/content/early/2012/05/11/1201544109.full.pdf+html doi/10.1073/pnas.1201544109] | |info=[http://www.pnas.org/content/early/2012/05/11/1201544109.full.pdf+html doi/10.1073/pnas.1201544109] | ||
|authors=Linley JE, Ooi L, Pettinger L, Kirton H, Boyle JP, | |authors=Linley JE, Ooi L, Pettinger L, Kirton H, Boyle JP, Peers C, Gampera N | ||
|year=2012 | |year=2012 | ||
|journal=Proc Natl Acad Sci U S A | |journal=Proc Natl Acad Sci U S A |
Revision as of 19:25, 15 May 2012
Linley JE, Ooi L, Pettinger L, Kirton H, Boyle JP, Chris Peers C, Gampera N (2012) Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons. Proc Natl Acad Sci U S A doi/10.1073/pnas.1201544109. |
ยป doi/10.1073/pnas.1201544109
Linley JE, Ooi L, Pettinger L, Kirton H, Boyle JP, Peers C, Gampera N (2012) Proc Natl Acad Sci U S A
Abstract: Substance P (SP) is a prominent neuromodulator, which is produced and released by peripheral damage-sensing (nociceptive) neurons; these neurons also express SP receptors. However, the mechanisms of peripheral SP signaling are poorly understood. We report a signaling pathway of SP in nociceptive neurons: Acting predominantly through NK1 receptors and Gi/o proteins, SP stimulates increased release of reactive oxygen species from the mitochondrial electron transport chain. Reactive oxygen species, functioning as second messengers, induce oxidative modification and augment M-type potassium channels, thereby suppressing excitability. This signaling cascade requires activation of phospholipase C but is largely uncoupled from the inositol 1,4,5-trisphosphate sensitive Ca2+ stores. In rats SP causes sensitization of TRPV1 and produces thermal hyperalgesia. However, the lack of coupling between SP signaling and inositol 1,4,5-trisphosphate sensitive Ca2+ stores, together with the augmenting effect onMchannels, renders the SP pathway ineffective to excite nociceptors acutely and produce spontaneous pain. Our study describes a mechanism for neurokinin signaling in sensory neurons and provides evidence that spontaneous pain and hyperalgesia can have distinct underlying mechanisms within a single nociceptive neuron. โข Keywords: dorsal root ganglia
โข O2k-Network Lab: UK Leeds Peers C
Labels:
Stress:RONS; Oxidative Stress"RONS; Oxidative Stress" is not in the list (Cell death, Cryopreservation, Ischemia-reperfusion, Permeability transition, Oxidative stress;RONS, Temperature, Hypoxia, Mitochondrial disease) of allowed values for the "Stress" property. Organism: Rat Tissue;cell: Neurons; Brain"Neurons; Brain" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property. Preparation: Intact Cell; Cultured; Primary"Intact Cell; Cultured; Primary" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.
Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
HRR: Oxygraph-2k