Loew 1963 Biochim Biophys Acta
From Bioblast
Revision as of 14:34, 24 November 2015 by Kandolf Georg (talk | contribs)
Loew H, Vallin I (1963) Succinate-linked diphosphopyridine nucleotide reduction in submitochondrial particles. Biochim Biophys Acta 69:361-4. |
Loew H, Vallin I (1963) Biochim Biophys Acta
Abstract:
- The reduction of added DPN by succinate catalyzed by submitochondrial particles from beef heart has been studied.
- The reduction was endergonic and required specifically the addition of ATP.
- The reaction had a limited specificity for electron acceptors; six DPN analogues tested were reduced at the same rate or nearly the same rate, as was DPN. TPN was only reduced at a very slow rate.
- The rate of reduction was influenced by phosphate and ADP and their effects became pronounced if added together.
- The effect of DPNH was marked only if added in a concentration equal to or exceeding that of DPN.
- Respiratory inhibitors acting in the flavin region of the respiratory chain blocked the reaction.
β’ Keywords: Succinate, DPN, ATP, Beef heart
Labels:
Organism: Bovines
Tissue;cell: Heart
Preparation: Isolated mitochondria
Enzyme: Complex II;succinate dehydrogenase
Regulation: ATP
Made history